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Caveolins in Vascular Smooth Muscle Form Organizing Function Cardiovascres Oxfordjournals
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People also ask
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What is the function of the vascular smooth muscle?
Function. Vascular smooth muscle contracts or relaxes to change both the volume of blood vessels and the local blood pressure, a mechanism that is responsible for the redistribution of the blood within the body to areas where it is needed (i.e. areas with temporarily enhanced oxygen consumption). -
What is the caveolin in muscle?
Caveolin-3 is the principal structural protein component of caveolae membrane domains in skeletal muscle cells. Caveolae are plasma membrane invaginations implicated in the regulation of signal transduction events. The roles that caveolin-3 plays in skeletal muscle cell physiology are becoming more apparent. -
What is caveolae in smooth muscle?
Caveolae are flask-shaped invaginations of the plasma membrane that are abundant features of smooth muscle. -
What is the function of Caveolin 3?
Caveolin-3 regulates several processes that play important roles at various stages of skeletal muscle development and repair [68,69,70]. Its expression is required for differentiation and efficient fusion of myoblast and myotube formation [69,70,71]. -
What cellular process does caveolin play a role in?
Some of the processes associated with caveolae include endocytosis, exocytosis, cholesterol homeostasis and signal transduction [20]. -
What is the function of caveolae in smooth muscle cells?
Additional research suggests that caveolae and caveolins may help modulate smooth muscle cell contraction via interaction with several ion channels and receptors. Caveolae have been implicated in the signal transduction of 5-HT2A receptor, which is the primary mediator of smooth muscle contraction in response to 5-HT. -
What is the function of the caveolins?
The caveolin proteins (caveolin-1, -2, and -3) serve as the structural components of caveolae, while also functioning as scaffolding proteins, capable of recruiting numerous signaling molecules to caveolae, as well as regulating their activity. -
What is the CAV3 gene muscle disease?
CAV3-related distal myopathy is part of a group of conditions called caveolinopathies, which are muscle disorders caused by mutations in the CAV3 gene. The CAV3 gene provides instructions for making a protein called caveolin-3, which is found in the membrane surrounding muscle cells.
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