
Caveolins in Vascular Smooth Muscle Form Organizing Function Cardiovascres Oxfordjournals
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People also ask
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What is the role of caveolae in smooth muscle?
Caveolae, therefore, may be specialized plasmalemmal regions involved in the integration of extracellular contractile signals and intracellular effectors in smooth muscle.
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Which type of muscle has caveolae?
Caveolae exist in most mammalian cell types and are especially abundant in adipocytes, endothelial cells, fibroblasts, smooth-muscle cells, and type I pneumocytes (Couet et al., 1997).
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What is the function of caveolae mediated endocytosis?
Nowadays, it is generally accepted that caveola-mediated endocytosis functions as a true uptake mechanism parallel to the clathrin-mediated pathway. Being ligand-triggered, caveolar endocytosis provides a more selective and highly regulated way for uptake of specified substances.
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What is the function of vascular smooth muscle and its role in vascular repair?
Vascular smooth muscle cells (VSMCs) constitute the major cells in the wall of blood vessels. The main role of vascular smooth muscle is to redistribute blood within the body by contracting and dilating in response to stimuli, thus changing the volume of blood vessels and the local blood pressure.
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What is the function of caveolae in smooth muscle?
Caveolae thus appear to constitute an important signalling domain that plays a role not only in regulation of smooth muscle tone, but also in proliferation, such as seen in neointima formation and atherosclerosis.
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What are caveolae in muscle cells?
Caveolae are expressed in various tissues and cell types, such as smooth muscle, fibroblasts, endothelial cells, macrophages and adipocytes. The functions of caveolae are diverse and include endocytosis, transcytosis, potocytosis, calcium signaling, and regulation of various signaling events (Parton and Simons, 2007).
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What is vascular smooth muscle cell VSMC proliferation?
Excess proliferation of vascular smooth muscle cells (VSMCs) results in vascular remodelling and serves a key role in several vascular disorders, including restenosis (1,2), atherosclerosis (3) and pulmonary artery hypertension (4). However, the molecular mechanism underlying VSMC proliferation remains unclear.
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What is the function of the caveolae?
Caveolae can bud from the plasma membrane to form an endocytic vesicle or can flatten into the membrane to help cells withstand mechanical stress. The role of caveolae as mechanoprotective and signal transduction elements is reviewed in the context of disease conditions associated with caveola dysfunction.
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