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Transcriptional Activity of ATF3 in the Stromal Carcinogenesis Carcin Oxfordjournals Form
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What is the full name of ATF3?
ATF3 activating transcription factor 3 [Homo sapiens (human)] - Gene - NCBI. The . gov means it's official. Federal government websites often end in . -
What does the ATF gene do?
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. -
What is the disease ATF3?
The abnormalities of ATF3 expression and regulation have been observed in the pathogenesis of various diseases, such as cancer, cardiac remodeling, rheumatoid arthritis, and microvascular injury (25,31-33). -
What is the role of ATF3 in cancer?
ATF3 functions as an oncogene or tumor suppressor in prostate cancer. ATF3 may be upregulated by androgen, thus induces cell proliferation and G1-to-S-phase transition of the cell cycle. In addition, ATF3 SUMOylation enhanced cyclin D1 (CCND1) activation, resulting in increased cell proliferation and colony formation. -
What is overexpression of ATF3?
ATF3 overexpression protects against cardiac microvascular I/R injury in part by inhibiting the TLR4/NF-κB pathway and oxidative stress. Keywords: Ischemia/reperfusion; activating transcription factor 3; inflammatory response; microvascular injury; oxidative stress; toll-like receptor 4. -
How does the ATF3 gene impact our immune systems?
Thus, by dampening the expression of proinflammatory genes, ATF3 prevents the immune system from overreacting. Strikingly, this effect is not limited to TLR4 signaling; ATF3 acts as a negative regulator in TLR2/6, TLR3, TLR4, TLR5, TLR7, and TLR9 signaling in macrophages, as shown by Williams and colleagues (68). -
What does ATF3 do?
ATF3 functions as an oncogene or tumor suppressor in prostate cancer. ATF3 may be upregulated by androgen, thus induces cell proliferation and G1-to-S-phase transition of the cell cycle. In addition, ATF3 SUMOylation enhanced cyclin D1 (CCND1) activation, resulting in increased cell proliferation and colony formation. -
How is ATF3 activated?
Activating transcription factor 3 (ATF3) gene encodes a member of the ATF family of transcription factors and is induced by various stress signals, including many of those that induce the unfolded protein response (UPR).
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