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Transcriptional Activity of ATF3 in the Stromal Carcinogenesis Carcin Oxfordjournals Form
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People also ask
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What signaling pathway is ATF3?
for example, found that ATF3 is induced by proinflammatory cytokines, glucose, and palmitate in ß cells (25). ATF3 induction is partially mediated by the NF-κB and JNK/stress-activated protein kinase (SAPK) signaling pathways, which are two stress-induced pathways involved in diabetes.
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What does the ATF3 gene do?
Study identified ATF3 as a tumor suppressor for inhibiting cell proliferation and metastasis in hepatocellular carcinoma (HCC) through targeting and regulating CYR61. Clinically, ATF3 was down-regulated in HCC tissues, and its expression signNowly associated with intrahepatic metastases and overall survival.
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What is the mechanism of ATF3?
The mechanism of ATF3 exertion of its negative regulation function was identified. Acetylation and deacetylation of histones is very important for transcription by chromatin remodeling; while acetylation says 'go' to the transcription factors, deacetylation says 'stop'.
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What is the function of ATF3?
In summary, ATF3 has different functions in regulating glucose homeostasis. In the pancreas, ATF3 upregulates the expression levels of peptide hormone genes (e.g., proglucagon and glucagon), apoptosis-related genes (e.g., Noxa and Bnip3), and inflammation-related genes (e.g., TNFα, IL-1β, IL-6, and Ccl2).
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How does the ATF3 gene impact our immune systems?
ATF3 controls the extent of Toll-like receptor (TLR)-induced immune response (17, 67) and can influence glucose levels by regulating β-cell viability and function (23, 76).
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What is the ATF3 gene expression?
A strong body of evidence shows that ATF3 is an adaptive-response gene and that its expression is increased by numerous signals, including those triggered by genotoxic agents, cytokines, cell death-inducing agents, and physiological stresses (5, 11, 19, 23).
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