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People also ask
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What is the voltage-gated sodium channel in the heart?
Cardiac voltage-gated sodium channels are transmembrane proteins located in the cell membrane of cardiomyocytes. Influx of sodium ions through these ion channels is responsible for the initial fast upstroke of the cardiac action potential.
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What are voltage-dependent Na+ channels?
Voltage-gated sodium channels (VGSCs), also known as voltage-dependent sodium channels (VDSCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the sodium ion Na+.
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What is a voltage sensitive sodium channel?
Voltage-gated sodium channels (VGSCs) are the basic ion channels for neuronal excitability, which are crucial for the resting potential and the generation and propagation of action potentials in neurons. To date, at least nine distinct sodium channel isoforms have been detected in the nervous system.
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What are the characteristics of voltage-gated sodium channels?
9 Na+ channels are mainly distributed in the PNS (especially in the spinal nerve system). Normal VGSCs have three main features: (1) voltage-dependent activation; (2) rapid inactivation; and (3) Na+ selectivity. The α subunit is the dominant subunit of VGSCs and is responsible for normal electrophysiological function.
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What are the voltage-gated sodium channels?
Voltage-gated sodium channels are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types [30,32]. They are also expressed at low levels in nonexcitable cells, where their physiological role is unclear [3].
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What is the voltage-dependent sodium channel in the heart?
Voltage-gated sodium (Na) channels are transmembrane proteins responsible for the rapid upstroke of the cardiac action potential, and for rapid impulse conduction through cardiac tissue.
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What is a voltage-dependent sodium channel?
Voltage-gated sodium channels (VGSCs), also known as voltage-dependent sodium channels (VDSCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the sodium ion Na+.
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What determines the activity of the voltage-gated Na+ channel?
Voltage-gated ion channels (VGICs) are transmembrane proteins that play important roles in the electrical signaling of cells. The activity of VGICs is regulated by the membrane potential of a cell, and open channels allow the movement of ions along an electrochemical gradient across cellular membranes.
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