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Identification of PN1, a Predominant Voltage Dependent Sodium  Form

Identification of PN1, a Predominant Voltage Dependent Sodium Form

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let's talk about the activation cycle of voltage-gated sodium channels in order to understand the different functional states that a voltage-gated sodium channel can occupy I have to first consider a few important structural features of these channels first of all these channels have four voltage sensor domains only showing two of them here the voltage sensor domains are the locations of the channels voltage sensors the voltage sensors are transmembrane regions of the channels that are enriched and positively charged amino acids within the primary structure the presence of these charges makes them sensitive to the presence of a membrane potential or the electrical field across the membrane next the core of the channel protein is comprised of these pore forming domains the pore forming domains have a couple of important structural features so first of all this is where the location of the selectivity filter is the selectivity filter lines the channel pore and this is what determ

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