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UDP Glucuronosyl Transferase 1A1 UGT1A1, Full Gene Childrensmn  Form

UDP Glucuronosyl Transferase 1A1 UGT1A1, Full Gene Childrensmn Form

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This is a summary of the CPIC dosing guideline for atazanavir and variation in the gene UGT1A1. This guideline was last updated in September 2015. Due to the risk of bilirubin-related discontinuation of atazanavir in patients who are UGT1A1 poor metabolizers, it is recommended to consider an alternative agent in these patients, particularly where jaundice would be of concern. In patients who are UGT1A1 intermediate or extensive metabolizers, there is no need to avoid prescribing atazanavir based on the UGT1A1 genetic test result. This image is adapted from the PharmGKB atazanavir pathway. A link to the original pathway is provided in the description below the video. Atazanavir is used to treat HIV infection. It is known to inhibit the protein UGT1A1. UGT1A1 is responsible for the glucuronidation of hundreds of compounds. This glucuronidation makes compounds water soluble, allowing for their biliary or renal elimination. One of the compounds that UGT1A1 glucuronidates is bilirubin. If U

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