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 AOC 034 DOC Code PIDMD Rev 6 11 W E a L T H of Case No  Courts Ky 2011

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[Music] Oh mate is the screening as I mentioned is a screening umbrella protocol and patients are identified through liquid biopsy and molecular profiling and then through the accrued network are identified for different basket trials under the umbrella protocol so currently we have several trials that are either in activation phase or or enrolling patients these include anti her2 EGFR reach challenge FGFR altered patients and many others we also have a big basket for patients who might have not have any currently actionable alterations so this is hopefully going to help identify more treatment options for many colorectal cancer patients who have already received the standard therapeutics the real benefit to liquid biopsies one of the benefits is that we can monitor in real time patients response through through the cell-free DNA we can also identify whether they are responding earlier perhaps than CT scans or other imaging modalities we will hopefully be able to identify mechanisms of

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