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 V940 2019

V940 2019-2025 Form

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so this is an mRNA vaccine that takes it's an antigen vaccine made from a patient's own tumor up to 34 epitopes and then given to the patient in an adjuvant setting after two induction doses of pd-1 with pembralizumab this was a small study about 150 patients but really showed a relapse free survival benefit so the hazard ratio 0.56 so 44 percent Improvement in relapse free survival for at any time Point what's interesting about this is that it was compared to single Agent pembrolizum app which is the standard in this setting it to me is the introduction of a neoadjuvant type Paradigm in the adjuvant why do we like neoadiment therapy because tumor-associated antigens are available and you can get a stronger boost that was supported by swag 1801 presented by sapna Patel a better relapse free survival but those are in bulky stage three patients what do we do for the patients who unfortunately have come after their surgery what do we do for patients who don&#39

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