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Le220e Form

Le220e Form

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a novel automated high throughput plasma protein biomarker enrichment protocol plasma protein biomarker enrichment is necessary to increase the dynamic range of plasma biomarker identification in our lcms bottom-up analysis as you all know most of the plasma is made up by redundant proteins that don't give you anything in information such as albumin immunoglobulins etc the problem with depletion if you do this by affinity or other means is that there's an unpredictable co-depletion of biomarkers to do complex formation and thereby most people don't like this also these workflows are easily automatable and they are serial that means it's single columns or single tubes or serial of columns that you have to go over we looked for a solution by disrupting and dissociating protein complexes as they are coming under the matrix thereby disrupting co-depletion and we do this by adaptive focused acoustics or afa and i will explain that to you shortly so physically

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