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Gl3585e 052007 Cll Form

Gl3585e 052007 Cll Form

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today i'm going to discuss genomic evaluation of chronic lymphocytic leukemia and how our lab decided to transition from a snip array cgh platform to a ngs based cnv plus snv approach first i have no conflicts of interest to this closed as you well know cll is the most frequent adult leukemia in our populations with an annual incidence of two to six cases per 100 000 people it can manifest in a ganglionic form but most cases present as a leukemia characterized by a monoclonal lymphocytosis newly diagnosed or treatment naive patients are classified using the cll ipi which combines both clinical and genetic characteristics of the disease these characteristics define four risk lev levels with distinct overall and median survivals and will lead to the ultimate clinical decision to treat or not to treat the patient as you could see in the previous slide only the tp53 alterations mainly gene deletion has a specific value in the cll ipi on the other end in their recent clinical practice guide

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