
DGC OntariO DistriCt COunCil SCheDule 8 Standard Contract Dgc Form


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People also ask
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What is the function of the DGC?
The dystrophin glycoprotein complex (DGC) is a specialization of cardiac and skeletal muscle membrane. This large multicomponent complex has both mechanical stabilizing and signaling roles in mediating interactions between the cytoskeleton, membrane, and extracellular matrix.
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What is the pathophysiology of Duchenne muscular dystrophy?
Altered regeneration, inflammation, impaired vascular adaptation, and fibrosis are probably downstream events that take part in the muscular dystrophy and that probably vary a lot along species (i.e., mdx mice), probands within families, stressing the importance of epigenic factors.
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How does DGC work?
The DGC BC is a Membership organization and does not do any hiring for productions. Productions, also known as Employers, are responsible for finding and hiring their own crew. Anyone who is legally eligible to work in Canada can work as a Helper Production Assistant in BC.
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How does dystrophin cause muscular dystrophy?
Skeletal and cardiac muscle cells without enough functional dystrophin become damaged as the muscles repeatedly contract and relax with use. The damaged cells weaken and die over time, causing the characteristic muscle weakness and heart problems seen in Duchenne and Becker muscular dystrophy.
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How does dystrophin stabilize the sarcolemma of muscles?
At the cytoplasmic face of the sarcolemma, dystrophin maintains its membrane localization by interacting with β-dystroglycan. Dystrophin binds to the intracellular actin network to link the cytoskeleton to DGC, which in turns connects to basal lamina by interacting with ECM ligands.
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