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 Form Apl 002 2017

2017-2025 Form

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I bet this is a compliment company interested in the compliment pathways and specifically within the compliment pathways which many of you might have heard about in the context of its role in macular degeneration we are interested in complement factor C 3 which is the component that's it's centrally in the Cascade and by inhibiting that you have an effect on all of the downstream effectors that can play a role in pathology we don't only have clinical trials active in ophthalmology but in a wide range of indications and including some rare diseases and chronic obstructive pulmonary disease I will explain to in a minute what is these indications together we have two molecules and development the first one is called APL one it is a small cyclic peptide with 13 amino acids linked by disulphide bond and then APL 2 which is a long-acting version of APL 1a pegylated molecule that we use for both the intra vitriol and the systemic subcutaneous dosing so a bit about the

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