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UC LF 617  Form

UC LF 617 Form

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[MUSIC] Now we're going to talk about lutetium PSMA radio ligand therapy. So first let's start off talking about what is theranostics? This is the idea of using a molecule for both imaging, diagnostics, and therapy. In this example, on the blue side here, this is the binding portion of the molecule, of the urea motif that binds to PSMA. On the opposite side of the molecule in red, this is the curator. This is what carries the radio metal into the tumor. You can either put gallium or copper for imaging in there or for therapy you could put lutetium or actinium to treat a patient. We're using the same molecule for both imaging to select the patients and then subsequently to treat the patients with lutetium. This approach was evaluated in the vision trial. This was a randomized Phase 3 study in about 800 patients comparing lutetium PSMA 617 plus standard of care versus standard of care alone. Of note, there was no chemotherapy allowed in this trial, but the results demonstrated an improve

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