Uracil DNA N Glycosylase Distributively Interacts with Duplex Jbc Form

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hey guys quickback mr basics here let's talk about base excision repair besides uv radiation the nitrogenous base of dna can be damaged by a variety of mechanism such as oxidation alkylation and deamination the presence of these modified bases results in incorrect base pairing and mutations in the dna hence it becomes necessary for the cell to remove such chemically modified bases the removal of such chemically modified bases is done by the mechanism of base accession repair the enzyme involved in this repair mechanism is dna glycosylase the dna glycosylase identifies the modified base and removes them out of the double helix the empty region in the dna where the base has been removed is called ap site ap stands for a basic site which means it is devoid of any purine or pyramid in base sometimes it is also referred to as apurinic or a pyrimidine excited in the next step ap endonuclease cleaves this region to yield free 3-hydroxyl group and 5-phosphate group the dna polymerase then iden