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People also ask
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What is biotin covalently bound to?
Biotin serves as a coenzyme for acetyl-CoA carboxylases (ACC)α and ACCβ, propionyl-CoA carboxylase (PCC), 3-methylcrotonyl-CoA carboxylase (MCC) and pyruvate carboxylase (PC); biotin is covalently bound to the ε-amino group of a specific lysine residue in carboxylases [2].
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What binds biotin and prevents its absorption?
Dietary avidin, a glycoprotein in raw egg whites, binds tightly to dietary biotin and prevents biotin's absorption in the gastrointestinal tract [13,14]. Cooking denatures avidin, making it unable to interfere with biotin absorption [13].
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What enzyme does biotin inhibit?
A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis. J Biol Chem. 2002 May 10;277(19):16347-50.
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What role does ATP play in biotin-dependent enzymes?
What role does ATP play in biotin - dependent enzymes? It reduces bicarbonate.
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How is the biotin bound to the enzyme in biotin containing enzymes?
Biotin is a water-soluble vitamin. It is a cofactor for four ATP-dependent carboxylases: acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and β-methylcrotonyl-CoA carboxylase. Biotin occurs covalently bound to the enzymes via the terminal amino group of a lysine residue.
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What enzymes are involved in biotin?
Abstract. Biotin, a water-soluble vitamin, is used as cofactor of enzymes involved in carboxylation reactions. In humans, there are five biotin-dependent carboxylases: propionyl-CoA carboxylase; methylcrotonyl-CoA carboxylase; pyruvate carboxylase, and two forms of acetyl-CoA carboxylase.
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