
There Are Three Distinct Forms of Bombesin Jbc
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People also ask
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What are the effects of bombesin?
Bombesin can release gastrin and exert other pharmacologic effects on the gastrointestinal tract in mammals. Bombesin-like immunoreactivity is widely distributed in mammalian brain (including the hypothalamus), lung, and gastrointestinal (GI) tract.
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Where is bombesin released from?
Bombesin is a stimulator of gastrin release from G cells that involve stimulation of G-protein-coupled receptors: BBR (BRS) 1,2 and 3. The gastrointestinal G-cell secretes gastrin and is found in gastric and duodenal tissue.
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What is the bombesin family of peptides?
The bombesin family of peptides was originally isolated from frog skin extracts and includes bombesin, gastrin-releasing peptide (GRP; the mammalian homologue of bombesin), neuromedin B, and neuromedin C.
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What is the role of bombesin related peptides in the control of food intake?
Bombesin, GRP, and NMB have a role in the short-term control of food intake. These peptides reduce meal size (MS) and they prolong the intermeal interval (IMI), the time between the first and second meals.
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What is the function of the bombesin?
Bombesin is a peptide derived from a European frog that belongs to the bombesin family, along with gastrin releasing peptide and gastrin releasing peptide (18–27). It exhibits various biological actions such as smooth muscle contraction and hormone secretion.
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What is Bombesin also called?
BBS, bombesin; GRP(18–27), C-terminal fragment of gastrin-releasing peptide, also called neuromedin C; SP, substance P; Cpa, p -chlorophenylalanine; pGlu, pyroglutamic acid. b. Numbers refer to the amino acid position from the N terminus of bombesin.
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