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The Role of the DNA Damage Checkpoint Pathway in Intraductal Clincancerres Aacrjournals Form
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People also ask
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Why is the DNA damage checkpoint in G1 important?
The G1 to S checkpoint prevents replication of damaged DNA. Essentially, this process is able to arrest the cell cycle through the functions of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related, which phosphorylate a number of substrate proteins in response to DNA damage. -
What does the DNA damage checkpoint do?
DNA damage checkpoints are essential control points in the cell cycle ensuring effective damage repair. The loss of checkpoint functions leads to loss of genomic integrity and allows accumulation of genetic damage in the daughter cells. -
What may happen if the checkpoint is damaged?
If a checkpoint fails or if a cell suffers physical damage to chromosomes during cell division, or if it suffers a debilitating somatic mutation in a prior S phase, it may selfdestruct in response to a consequent biochemical anomaly. This is another example of apoptosis. -
What effect does the failure of DNA synthesis have on the cell cycle?
DNA replication errors, especially those occurring at regions that are hard to replicate, called fragile sites, can cause breaks in DNA. This can lead to cancer, primarily by making it more likely that fragments of chromosomes rearrange themselves, activating genes that lead to uncontrollable cell division. -
How does DNA damage affect the cell cycle?
The activation of the DNA damage checkpoint restrains the mitotic entry of cells containing DNA adducts by triggering a transduction pathway that ends up taking over the control of the cell cycle, thus blocking cells in G2/M. -
What happens if you damage your DNA cells?
Of course, DNA damage may also result in cell death which can have serious consequences for the organism of which the cell is a part; for example, loss of irreplaceable neurons in the brain. Accumulation of damaged DNA has also been considered to contribute to some of the features of aging. -
What happens when DNA is genetically damaged?
Because DNA is the repository of genetic information in each living cell, its integrity and stability are essential to life. DNA, however, is not inert; rather, it is a chemical entity subject to assault from the environment, and any resulting damage, if not repaired, will lead to mutation and possibly disease. -
What does DNA do in the cell cycle?
DNA's unique structure enables the molecule to copy itself during cell division. When a cell prepares to divide, the DNA helix splits down the middle and becomes two single strands. These single strands serve as templates for building two new, double-stranded DNA molecules - each a replica of the original DNA molecule. -
How does DNA damage effect the cell cycle?
The activation of the DNA damage checkpoint restrains the mitotic entry of cells containing DNA adducts by triggering a transduction pathway that ends up taking over the control of the cell cycle, thus blocking cells in G2/M. -
What does the DNA damage response do?
In response to DNA damage stress, cells utilize a variety of signaling pathways to activate different cellular processes. This signaling network functions to ensure a proper repair of the DNA breaks and/or eliminate cells with irreparable damage to allow the organism's survival.
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