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The Role of the DNA Damage Checkpoint Pathway in Intraductal Clincancerres Aacrjournals Form
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People also ask
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What do DNA checkpoints do?
By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated.
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What is the DNA damage response pathway?
What Is the DNA Damage Response Pathway? The DNA damage response (DDR) pathway is initiated by cells to repair DNA when they detect DNA damage. There are different types of DNA damage including endogenous DNA damage and exogenous DNA damage.
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What is the function of the checkpoint?
To monitor the progress and success of a single user during a load test in a more precise manner than viewing the full output of the virtual user, checkpoints are used to divide transactions into user-defined sections.
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What is the function of DNA damage?
DNA damage is an abnormal chemical structure in DNA, while a mutation is a change in the sequence of base pairs. DNA damages cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly.
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What role do the checkpoint kinases play in the DNA damage repair pathways?
Apical and downstream checkpoint kinases function coordinately to mediate cellular responses to DNA damage, either directly or through the regulation of additional downstream kinases. PIKKs also target an extensive network of substrates independently of downstream checkpoint kinases.
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What is the function of the DNA damage checkpoint?
DNA-damage checkpoints play important roles in diseases including cancer and aging [172]. They influence basic mechanisms of somatic and stem cell physiology, such as renewal, maintenance, and differentiation, but they also help prevent the development of cancer.
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What is the purpose of the DNA synthesis checkpoint?
The checkpoints detect various issues found on DNA. Once checkpoint proteins identify these issues, the cell activates signal transduction pathways in order to arrest the progression of the cell cycle and allow adequate time to fix the problems on DNA.
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What is the DNA damage checkpoint mechanism?
The DNA damage checkpoints employ damage sensor proteins, such as ATM, ATR, the Rad17-RFC complex, and the 9-1-1 complex, to detect DNA damage and to initiate signal transduction cascades that employ Chk1 and Chk2 Ser/Thr kinases and Cdc25 phosphatases.
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