HIV 1 Infected Blood Mononuclear Cells Form an Integrin and Agrin

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when HIV first enters the human bloodstream the virus circulates throughout the body the protective surface of HIV is studded with particular proteins called gp120 and inside is a capsid that contains the viral RNA and viral enzymes initially the gp120 protein on the virus is only able to bind to a cell surface protein on the macrophage called the cd4 receptor a second receptor protein ccr5 must also be present on the macrophage for the virus to enter the cell by endocytosis viral RNA and enzymes are released into the cell's cytoplasm reverse transcriptase uses the viral RNA to synthesize first a strand of viral DNA and then the complementary DNA strand the viral DNA then moves to the nucleus of the cell where it integrates into the host cell's DNA transcription of the DNA within the nucleus now results in the production of viral RNA this viral RNA can serve as the genome for new viruses and can be used as messenger RNA to produce viral proteins during translation by the ribosomes comp