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People also ask
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What is the generic for Sofosbuvir Velpatasvir?
Epclusa (sofosbuvir / velpatasvir) is a combination medication containing two antiviral medications, sofosbuvir and velpatasvir, that's used to treat chronic hepatitis C in adults and children.
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What are the authorized generics for HCV?
(NASDAQ: GILD) announced today plans to launch authorized generic versions of Epclusa® (sofosbuvir 400mg/velpatasvir 100mg) and Harvoni® (ledipasvir 90mg/sofosbuvir 400mg), Gilead's leading treatments for chronic hepatitis C virus (HCV), in the United States , through a newly created subsidiary, Asegua Therapeutics LLC ...
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What are the classes of HCV drugs?
There are four classes of DAAs, which are defined by their mechanism of action and therapeutic target. The four classes are nonstructural proteins 3/4A (NS3/4A) protease inhibitors (PIs), NS5B nucleoside polymerase inhibitors (NPIs), NS5B non-nucleoside polymerase inhibitors (NNPIs), and NS5A inhibitors [1].
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What is the FDA approved treatment for HCV?
The U.S. Food and Drug Administration approved Epclusa to treat adult patients with chronic hepatitis C virus (HCV) both with and without cirrhosis (advanced liver disease). For patients with moderate to severe cirrhosis (decompensated cirrhosis), Epclusa is approved for use in combination with the drug ribavirin.
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How much do Hep C meds cost?
Direct-acting antivirals (DAAs) are oral medications that can cure hepatitis C for most people. They are usually taken daily for 8 to 12 weeks and have few side effects. DAAs are costly without insurance. This treatment can cost $22,000 to $95,000 or more without coverage.
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Is generic Harvoni available?
Harvoni contains two active ingredients: ledipasvir and sofosbuvir. Some forms of Harvoni are available as the generic drug ledipasvir/sofosbuvir. Specifically, the 90 milligrams (mg) ledipasvir/400 mg sofosbuvir (90 mg/400 mg) strength of Harvoni oral tablet is available in a generic version.
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Does Mavyret require prior authorization?
Mavyret is recognized as a recommended regimen (12 weeks) for the treatment of patients with recurrent HCV post-liver transplantation (without cirrhosis or with compensated cirrhosis). Prior Authorization is recommended for prescription benefit coverage of Mavyret.
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