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People also ask
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What are prolactin and growth hormone receptors?
PRL and GH receptors are non-kinase receptors whose activation of signaling pathways requires participation of receptor-associated kinases, such as Janus kinases or Src kinases. Signal transduction by these receptors mainly involves the JAK/Stat pathway.
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What type of receptor is prolactin receptor?
The prolactin receptor (PRLR) belongs to the class I cytokine receptor superfamily, a family of single-pass transmembrane proteins that transduce signals following phosphorylation by cytoplasmic kinases. The human PRLR (hPRLR) gene is located on chromosome 5p14-p13.
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What is the structure of PRLR?
PRLR structure PRLR has three main domains: extracellular, transmembrane and intracellular. The extracellular domain is divided into two fibronectin domains, D1 and D2, and the WS motif in D2 acts as a molecular switch during ligand-bound activation of PRLR (25).
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What type of receptor signaling does prolactin use?
The prolactin receptor (PRLR) belongs to the class I cytokine receptor superfamily, a family of single-pass transmembrane proteins that transduce signals following phosphorylation by cytoplasmic kinases.
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What is prolactin receptor structure?
Structure. The prolactin receptor (PRLR) is a membrane-bound protein of the cytokine receptor superfamily. In humans, it is encoded by a single gene which contains 11 exons and is located on chromosome 5.
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What is the pathway of the prolactin receptor?
The prolactin signaling pathway is initiated by the binding of prolactin with the prolactin receptor (PRLR), a member of class I cytokine receptor superfamily (Binart et al. 2000), which is expressed in a variety of tissues.
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What is the structure and function of prolactin?
Prolactin contributes to hundreds of physiologic functions, but the two primary responsibilities are milk production and the development of mammary glands within breast tissues. Prolactin promotes the growth of mammary alveoli, which are the components of the mammary gland, where the actual production of milk occurs.
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What is the short form of prolactin?
The short form of the prolactin (PRL) receptor silences PRL induction of the beta-casein gene promoter. Mol Endocrinol.
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