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A Nuclear Compartment with Impact on Cytoplasmic MRNA Localization Form
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People also ask
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What is cytoplasmic localization of mRNA?
mRNA localization is a mechanism used by various organisms to control the spatial and temporal production of proteins. This process is a highly regulated event that requires multiple cis- and trans-acting elements that mediate the accurate localization of target mRNAs.
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How does RNA get into the cytoplasm?
The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes via mobile export receptors.
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What is necessary for the transport of mRNA from the nucleus to the cytoplasm?
All movement of molecules and macromolecules between the cytoplasm and the nucleus takes place through nuclear pore complexes (NPCs), very large macromolecular complexes that are the only channels connecting these compartments.
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How does mRNA come out of the nucleus?
This gene is first transcribed into mRNA in the nucleus of the cell. This mRNA can undergo processing in the nucleus. And once this is complete, the mature mRNA can then exit the nucleus through the nuclear pores to enter the cytoplasm. In the cytoplasm, the mRNA can bind to a specialized organelle called the ribosome.
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How does mRNA get from the nucleus to the cytoplasm?
Because the mRNAs are exported and translated normally, we assume that they are bound to the usual set of proteins that escort mRNAs from the sites of transcription in the nucleus, through the nuclear pores, and into the cytoplasm (1).
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How does mRNA move from the nucleus to the ribosomes in the cytoplasm?
mRNA formed in the nucleus is transported out of the nucleus and into the cytoplasm where it attaches to the ribosomes. Proteins are assembled on the ribosomes using the mRNA nucleotide sequence as a guide. Thus mRNA carries a “message” from the nucleus to the cytoplasm.
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What is the localization of mRNA in a cell?
The localization of mRNAs to subcellular compartments provides a mechanism for regulating gene expression with exquisite temporal and spatial control and recent studies suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains.
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