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Clinical Applications of Oligonucleotides Form

Clinical Applications of Oligonucleotides Form

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[MUSIC PLAYING] Hi, I'm Kathryn Brennan, and I'm an application scientist here at Waters Corporation. Among the many LC-MS analytical method development challenges for oligonucleotides, the most problematic is that they are polyanionic in nature and are known to non-specifically bind or adsorb to metal surfaces. This interaction negatively impacts chromatographic performance, often resulting in poor peak shape and issues with analyte recovery, ultimately limiting overall performance of the analytical method. Our newly introduced ACQUITY PREMIER System and Columns that use High Performance Surface, or HPS, technologies are specifically designed to prevent adsorption of metal-sensitive analytes, and we are able to significantly improve chromatographic performance. With the ACQUITY PREMIER System and Column, out of the box and with no column and system passivation required, improvements in peak shape and signal can be seen for an oligo deoxythymidine and the fully phosphor

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