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Dshs 13 720 Form

Dshs 13 720 Form

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hello i am rahul prasad saath the talk at university of minnesota medical school the pathogenesis of pancreatitis is poorly understood for over a century we have known that trypsin activation is the central event early during panelititis recently endoplasmic reticulum stress has been found to be activated what we do not understand is how endoplasmic reticulum stress also an early event and trypsin activation another early event how are they related truths northern activation takes place in special co-localization compartments where lyrosomal fraction and samus and granules collocates and the lysosomal enzyme catheters in v activates trypsinosis protrypsin in this study we have used knockout mice which either lack trypsinosis or catastrophe and due to this genotype these mice do not demonstrate pathological inactivation the objective of this slide is to demonstrate what are the molecular targets that can be studied in the lab which demonstrate er stress so to answer the first question w

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