What would an ideal drug discovery/drug development process look like?

Some great answers covering a number of key ideas. I have a slightly different (slightly off topic) thought. I hope it can be considered relevant.An ideal drug discovery / development process would be one that is completely decoupled from the whims of investors and banks. Whilst there are many, many inefficiencies and pitfalls available for the drug discovery process to fall prey to (I speak from experience here!), the biggest step we could take to make the process ideal would be to remove all concept of return-on-investment / profit making from the process. This can be illustrated pretty simply:Average desired time-frame for an investor or VC to achieve 5-10 fold return on investment : 3-5 yearsAverage acceptable tenure for a CEO within the sector : 3-5 years (?) Time to design and develop a successful drug, from concept through to market: 15-20 yearsIt doesn't take a genius to see there is a clear disconnect here.Until the money required to perform the science is linked to a realistic time-frame and expectation, the drug discovery process will continue to falter: Scientific research is not a true process in the classical business sense and it's practitioners require time to actually, well, search. Bringing unrealistic (i.e. fixed!) time frames into the process is only going to result in low quality products designed to appease the money masters and ultimately result in a failure.Once we've solved that little conundrum (!), and to truly answer your question, I would say the ideal drug discovery process would look like this:1) Smart academic group make signNow, robust discovery concerning the involvement of a particular protein in a particular disease (Year 0)2) Drug discovery groups (i.e. biotech / pharma / research institutes) discover a relevant means of interfering with this protein (biologic or small molecule starting point) (Year 1)3) Medicinal chemists and / or molecular biologists turn the starting point into a product capable of being a drug (i.e. improving the potency, thus lowering the dose; modifying and stabilizing the product such that it can be administered in the desired manner with the desired dosing regimen) (Years 2-5)4) Prepare the product for phase I clinical trials, including preliminary toxicology and establishing a means for manufacturing on the required scale (Years 6-8)5) Phase I trials (Year 9)6) Prepare for Phase II trials (Years 10-11)7) Phase II trials (Year 12)8) Analysis of Phase II data (Year 13)9) Prepare Phase III (Year 14)10) Phase III trials (Years 15-16)11) Analysis of Phase III data (Year 17)12) Regulatory filing and regulatory body decisions (Years 18-19)13) To Market! (Year 20)

How do I get Google to remove an ad for a restricted product? I flag it in Google Chrome, fill out the form for a Google violation and no response.

You can fill out this form Feedback on AdWords AdsAs you can see Fireworks isn't an option on the list of violations. My best guess is this just isn't a top priority for Google since there are much more important issues they need to weed out like illegal drugs. Though it is clearly listed as disallowed in the Fireworks - Advertising Policies Help section enforcement varies between different policies.Often it's a waste of time and energy to try and get your competitor's ads blocked so I wouldn't bother.

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The four phases of clinical trials. Tens of thousands of treatments to prevent and treat diseases are available to people today. How do we know that they are safe and work well? Clinical trials. A clinical trial is a research study that tests new treatments or medical devices in people who volunteer to take part. To be approved for use, the results from clinical trials must show that a new treatment is safe for people to take and works well. Only then can the U.S. Food and Drug Administration (or FDA) approve it for use by the public. The FDA is the government agency that protects the public’s health by reviewing and approving treatments, medicines and other medical products. How do clinical trials test new treatments? Most new treatments go through four phases of clinical trials. Each phase has different goals, and a treatment will only move to the next phase if results show it is safe and works. The most important thing to researchers is participants’ safety. They desig

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What would an ideal drug discovery/drug development process look like?
Some great answers covering a number of key ideas. I have a slightly different (slightly off topic) thought. I hope it can be considered relevant.An ideal drug discovery / development process would be one that is completely decoupled from the whims of investors and banks. Whilst there are many, many inefficiencies and pitfalls available for the drug discovery process to fall prey to (I speak from experience here!), the biggest step we could take to make the process ideal would be to remove all concept of return-on-investment / profit making from the process. This can be illustrated pretty simply:Average desired time-frame for an investor or VC to achieve 5-10 fold return on investment : 3-5 yearsAverage "acceptable" tenure for a CEO within the sector : 3-5 years (?) Time to design and develop a successful drug, from concept through to market: 15-20 yearsIt doesn't take a genius to see there is a clear disconnect here.Until the money required to perform the science is linked to a realistic time-frame and expectation, the drug discovery process will continue to falter: Scientific research is not a true process in the classical business sense and it's practitioners require time to actually, well, search. Bringing unrealistic (i.e. fixed!) time frames into the process is only going to result in low quality products designed to appease the money masters and ultimately result in a failure.Once we've solved that little conundrum (!), and to truly answer your question, I would say the ideal drug discovery process would look like this:1) Smart academic group make signNow, robust discovery concerning the involvement of a particular protein in a particular disease (Year 0)2) Drug discovery groups (i.e. biotech / pharma / research institutes) discover a relevant means of interfering with this protein (biologic or small molecule starting point) (Year 1)3) Medicinal chemists and / or molecular biologists turn the starting point into a product capable of being a drug (i.e. improving the potency, thus lowering the dose; modifying and stabilizing the product such that it can be administered in the desired manner with the desired dosing regimen) (Years 2-5)4) Prepare the product for phase I clinical trials, including preliminary toxicology and establishing a means for manufacturing on the required scale (Years 6-8)5) Phase I trials (Year 9)6) Prepare for Phase II trials (Years 10-11)7) Phase II trials (Year 12)8) Analysis of Phase II data (Year 13)9) Prepare Phase III (Year 14)10) Phase III trials (Years 15-16)11) Analysis of Phase III data (Year 17)12) Regulatory filing and regulatory body decisions (Years 18-19)13) To Market! (Year 20)
How do I get Google to remove an ad for a "restricted" product? I flag it in Google Chrome, fill out the form for a Google violation and no response.
You can fill out this form Feedback on AdWords AdsAs you can see Fireworks isn't an option on the list of violations. My best guess is this just isn't a top priority for Google since there are much more important issues they need to weed out like illegal drugs. Though it is clearly listed as disallowed in the Fireworks - Advertising Policies Help section enforcement varies between different policies.Often it's a waste of time and energy to try and get your competitor's ads blocked so I wouldn't bother.

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How to create an eSignature for the cancer drug and biological products clinical data in marketing applications

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How to create an electronic signature for your Cancer Drug And Biological Products Clinical Data In Marketing Applications in Chrome

How to generate an electronic signature for signing the Cancer Drug And Biological Products Clinical Data In Marketing Applications in Gmail

How to make an eSignature for the Cancer Drug And Biological Products Clinical Data In Marketing Applications straight from your mobile device

How to make an eSignature for the Cancer Drug And Biological Products Clinical Data In Marketing Applications on iOS devices

How to generate an electronic signature for the Cancer Drug And Biological Products Clinical Data In Marketing Applications on Android

How to make an eSignature for the Cancer Drug And Biological Products Clinical Data In Marketing Applications in the online mode

Follow the step-by-step instructions below to eSign your cancer drug and biological products clinical data in marketing applications:

How to create an electronic signature for your Cancer Drug And Biological Products Clinical Data In Marketing Applications in Chrome

The guidelines below will help you create an eSignature for signing cancer drug and biological products clinical data in marketing applications in Chrome:

How to generate an electronic signature for signing the Cancer Drug And Biological Products Clinical Data In Marketing Applications in Gmail

Below are five simple steps to get your cancer drug and biological products clinical data in marketing applications eSigned without leaving your Gmail account:

How to make an eSignature for the Cancer Drug And Biological Products Clinical Data In Marketing Applications straight from your mobile device

Get cancer drug and biological products clinical data in marketing applications signed right from your smartphone using these six tips:

How to make an eSignature for the Cancer Drug And Biological Products Clinical Data In Marketing Applications on iOS devices

To sign a cancer drug and biological products clinical data in marketing applications right from your iPhone or iPad, just follow these brief guidelines:

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