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yeah so in this study that we developed together with muet Cancer Institute Kar University of Memorial long cing we sequenced for the first time a large series or relatively large of 74 patients with multiple Mel treated with anti-bcma C therapy and what we found is that H genome sequencing so the simple DNA genomic profiling identifying which alterations are different between the tumor and the normal allow us to basically identify all the patients that progress all the patient that did not respond like the refractory the one that after 100 days are still with a lot of disease and we also identify patients that have a great response like many years of remission and that makes a lot of sense biologically and what we found is that these alterations are of genomic instability that allow the loss of alterations that makes the plasma cell less plasma cells so reducing bcma or have a better capability to escape bcma therapy what is interesting that some of these patients can respond to other

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