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hello I'm gene time one of the pediatric gastroenterologist here at the Mayo Clinic today I would like to discuss infliximab for patients with severe ulcerative colitis first a little background infliximab otherwise known as Remicade was approved for Crohn's disease in 1997 subsequently the Act one an act to clinical trials demonstrated it could have also be useful for patients with ulcerative colitis and led to its approval in 2005 the typical schedule for both Crohn's and ulcerative colitis is to give an induction schedule that means we give it at week zero two and six and then a maintenance schedule of every eight weeks however in patients with severe ulcerative colitis infliximab may actually still not prevent surgery when we looked at our Mayo Clinic experience 36 percent of patients still required surgery within a year otherwise known as a colectomy those who improved enough to receive an induction schedule all three doses of the induction schedule were more likely to avoid surge

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