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A Novel Polymorphism in Human Cytosine DNA Methyltransferase Cancerres Aacrjournals Form
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People also ask
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What is the function of cytosine methyltransferase?
It belongs to the family of other methyltransferases like DNMT1 and DNMT3B. The major functions of these enzymes are that they involved in adding methyl groups to the cytosine residue of CpG dinucleotides and thus play an important role in the epigenetic regulation of genes.
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What are methyltransferase like proteins?
Methyltransferase-like protein is a ubiquitous enzyme-like protein in the human body, with binding domains for nucleic acids, proteins and other small molecules, and plays an important role in a variety of biological behaviours in normal organisms and diseases, characterised by the presence of a methyltransferase-like ...
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What protein causes DNA methylation?
The known methyl-DNA-binding proteins have unique domains responsible for DNA methylation recognition: (1) the methyl-CpG-binding domain (MBD), (2) the C2H2 zinc finger domain, and (3) the SET- and RING finger-associated (SRA) domain.
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What is an example of a methyltransferase?
Important examples of this enzyme class in humans include phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine to epinephrine, and histamine N-methyltransferase (HNMT), which methylates histamine in the process of histamine metabolism.
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Which protein S could be a DNA methyltransferase?
DNA methyltransferases (DNMTs), responsible for the transfer of a methyl group from the universal methyl donor, S-adenosyl-L-methionine (SAM), to the 5-position of cytosine residues in DNA, are essential for mammalian development1. There are four members of the DNMT family, including DNMT1, DNMT3A, DNMT3B and DNMT3L.
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Which protein could be a DNA methyltransferase?
DNA methylation is catalyzed by three independently encoded DNA methyltransferases (DNMTs), such as DNMT1, DNMT3A, and DNMT3B. DNMT1 is a maintenance methyltransferase, whereas the other two are de novo methyltransferases. Mammalian DNMT1 is a multidomain enzyme (Zhang et al., 1999; Patra et al., 2003).
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What does DNA methyltransferase do?
DNA methyltransferases (DNMTs), responsible for the transfer of a methyl group from the universal methyl donor, S-adenosyl-L-methionine (SAM), to the 5-position of cytosine residues in DNA, are essential for mammalian development1.
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Does DNA methyltransferase increase gene expression?
Abstract. A large body of evidence demonstrates that DNA methylation plays a role in gene regulation in animal cells. Not only is there a correlation between gene transcription and undermethylation, but also transfection experiments clearly show that the presence of methyl moieties inhibits gene expression in vivo.
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