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let's talk about the astrocytic glutamate glutamine cycle astrocyte take part in formation of tripartite synapse if we zoom into a tripartite synapse we can see the presynaptic terminal postsynaptic terminal and astrocyte in the presynaptic terminal when action potential reaches the Terminus there would be release in glutamate and glutamate binds to postsynaptic glutamate receptor glutamate is formed from the presynaptic glutamine with the help of enzyme glutaminease astrocytes actually provide glutamine but how does astrocyte makes the glutamine astrocyte uptake excess glutamate with the help of excitatory amino acid transporter and that glucamide gets converted to glutamine with the help of glutamine synthetase and this is how astrocyte clears up excess of glutamate from the synapse and prevents the risk of excitotoxicity too much too much of glutamate is bad for the brain and it might lead to epilepsy that's why astrocity is important

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