Application of Active Site Derived Pharmacophores with Informative Genomics10 Bu

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most chemical reactions did not occur spontaneously in a cell instead cells rely on proteins called enzymes to kick-start chemical reactions and speed them up enabling cells to get the most of the energy sources available to them enzymes have a unique way of kick-starting reactions they work by binding to one or more specific molecules called reactants or substrates binding occurs at a special region on the enzyme called the active site once the substrates bind to the active site they form what's called an enzyme substrate complex as the enzyme and substrates begin to react some of the chemical bonds and the substrates begin to weaken causing them to link together eventually the chemical reactions at the active site lead to the formation of a different molecule this is referred to as the product once the reaction has occurred the product is released from the active site the enzyme returns to its original state and is free to react again with another set of substrates