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Effects of the Isoform Specific Characteristics of ATF6 and ATF6 on Bio Sdsu
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People also ask
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What is the function of the ATF6 protein?
Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis. Multiexon deletion alleles of ATF6 linked to achromatopsia. The Epstein-Barr Virus Lytic Protein BMLF1 Induces Upregulation of GRP78 Expression through ATF6 Activation. -
Is ATF6 a transcription factor?
ATF6 is an ER-membrane-bound transcription factor activated by ER stress-induced proteolysis which consists of two closely related factors, ATF6alpha and ATF6beta, in mammals. ATF6alpha but not ATF6beta plays an important role in transcriptional control. -
What does the ATF6 protein do?
Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis. Multiexon deletion alleles of ATF6 linked to achromatopsia. The Epstein-Barr Virus Lytic Protein BMLF1 Induces Upregulation of GRP78 Expression through ATF6 Activation. -
What does the unfolded protein response do?
The UPR is activated when unfolded proteins accumulate in the endoplasmic reticulum. This accumulation puts a greater load on the molecules in charge of folding the proteins, and therefore the UPR works to balance this by lowering the number of unfolded proteins present in the cell. -
What are the binding sites for ATF6?
ATF6 normally binds to the bipartite ER stress response element (ERSE) I (CCAAT-N9-CCACG/A), or ERSE II (ATTGG-N1-CCACG) of the promoter of target genes, in the presence of the CCAAT box binding factors20. -
How is ATF6 activated?
ATF6 is activated in response to ER stress through a mechanism involving reduction and monomerization of ATF6 oligomers, increased trafficking to the Golgi, and subsequent proteolytic processing by Site 1 and Site 2 proteases (S1P and S2P, respectively) [24]. -
How is ATF6 activated?
ATF6 is activated in response to ER stress through a mechanism involving reduction and monomerization of ATF6 oligomers, increased trafficking to the Golgi, and subsequent proteolytic processing by Site 1 and Site 2 proteases (S1P and S2P, respectively) [24].
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