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NORC Final ReportVol 1 Report Arc  Form

NORC Final ReportVol 1 Report Arc Form

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so ABB v400 is tusm abadis tan so it's a um anti-at antibody conjugated to a topo suas 1 inhibitor payload chemotherapy payload this antibody this is an antibody drug conjugate so it's designed to attach to CET that is the Target and CET is broadly expressed in many Advanced solid tumors including uh the tumor type uh that I'll discuss which gastrosoph adnoc carcinoma so this was studied in a in an expansion cohort um about half the patients had prospective selection for CED expression the other half did not um what we found is that this therapy is active um at the 3 migr per kilogram dose level U we noted a response rate approaching 29% with a progression free survival of 4 months and this is in a group of heavily pre-treated patients uh where the current standard of care has fairly low response rates and low progression free survival but also importantly we saw that the therapy was relatively well tolerated we did note um some Milo supression related to the ch

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