
Sapropterin for BH4 Deficiency Initial and Continuing PBS Authority Application Form


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People also ask
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How do you treat BH4 deficiency?
Treatment of BH4 deficiencies consists of BH4 supplementation (2-20 mg/kg per day) or diet to control blood phenylalanine concentration and replacement therapy with neurotransmitters precausers (L-dopa/CarbiDOPA and 5-hydroxytryptophan), and supplements of folinic acid in DHPR deficiency.
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What class of drug is Sapropterin dihydrochloride?
Sapropterin is in a class of medications called cofactors. It works by helping the body to break down phenylalanine so it will not build up in the blood.
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How do you test for BH4 deficiency?
Since 1980, BH4 metabolism had been screened in 2,186 babies with hyperphenylalaninemia, using measurement of pteridines in urine to recognize BH4 synthesis deficiency (GTPCH and PTPS deficiency) and direct DHPR assay in dried blood samples to recognize DHPR deficiency.
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Is sapropterin treatment for phenylketonuria?
There is evidence of short‐term benefit from using sapropterin in some people with sapropterin‐responsive forms of phenylketonuria; blood phenylalanine concentration is lowered and protein tolerance increased. There are no serious adverse events associated with using sapropterin in the short term.
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What is BH4 treatment for PKU?
Tetrahydrobiopterin (BH4) has been shown to enhance PAH activity in a subset of PKU patients and has been FDA-approved as an adjunct to dietary therapy. In addition, BH4 may allow responders to maintain plasma Phe within a treatment range while increasing protein intake [24,25,29,30].
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How much does sapropterin cost?
The cost for sapropterin 100 mg oral powder for reconstitution is around $1,119 for a supply of 30 powder for reconstitution, depending on the pharmacy you visit.
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What is the mechanism of action of sapropterin?
Sapropterin dihydrochloride is a synthetic form of cofactor BH4. Excess of cofactor activates residual PAH enzyme, improving phenylalanine metabolism and decreasing phenylalanine concentrations in the blood of PKU patients. In patients with BH4 deficiency, sapropterin provides an effective alternative to BH4.
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What is sapropterin used for?
Sapropterin is used to lower phenylalanine levels in the blood of patients with phenylketonuria (PKU). High levels of phenylalanine (an amino acid) in the blood can cause severe brain damage, including severe mental retardation, seizures, tremors, or decreased learning ability.
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