AMRA Report North American MH Registry Mhreg Form
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People also ask
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What is fulminant malignant hyperthermia?
Christened "malignant hyperpyrexia,"1 "profound hyperthermia,"2 or "fulminant hyperthermia,"3 it consists of accelerating hypermetabolism and high fever appearing after the onset of general anesthesia. Victims of this entity may be otherwise good anesthetic risks undergoing surgery which is itself not formidable.
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What are the cardinal signs of malignant hyperthermia?
Symptoms of Malignant Hyperthermia Often, the first signs are rapid breathing, a fast heart rate, and muscle rigidity, especially in the jaw. Temperature usually becomes extremely high (usually over 104° [40° C] and sometimes higher than 109° F [43° C]). Abnormal heart rhythms, nausea, and vomiting may occur.
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Which disease is most associated with malignant hyperthermia?
While malignant hyperthermia often occurs in people without other serious medical problems, certain inherited muscle diseases (including central core disease, multiminicore disease, and STAC3 disorder) are associated with malignant hyperthermia susceptibility.
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What are the non specific clinical signs of malignant hyperthermia?
The classic signs of MH include hyperthermia to marked degree, tachycardia, tachypnea, increased carbon dioxide production, increased oxygen consumption, acidosis, muscle rigidity, and rhabdomyolysis, all related to a hypermetabolic response. The syndrome is likely to be fatal if untreated.
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What is the main trigger of malignant hyperthermia?
Malignant hyperthermia (MH) is a hypermetabolic response to potent inhalation agents (such as halothane, sevoflurane, desflurane), the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stresses such as vigorous exercise and heat.
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What is the malignant hyperthermia hotline?
You quickly dial 800-644-9737, the hotline of the Malignant Hyperthermia Association of the United States (MHAUS).
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What is fulminant Hypermetabolism of skeletal muscle?
Malignant hyperthermia (MH) is a dominantly inherited disorder of skeletal muscle that predisposes susceptible individuals to a life threatening adverse reaction (fulminant MH event) upon exposure to potent volatile anesthetics (halothane, isoflurane, sevoflurane, desflurane, etc.)
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What are the guidelines for malignant hyperthermia?
Three approaches to reversing the malignant hyperthermia process should be applied together: eliminate the trigger agent; give intravenous (i.v.) dantrolene; and start active body cooling. Activated charcoal filters should be available at all locations where general anaesthesia is administered.
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