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The Vpu Protein of Human Immunodeficiency Virus Type 1 Forms
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People also ask
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What is human immunodeficiency virus type 1 assembly release and maturation?
The process of HIV‐1 assembly, release, and maturation results in the production of a mature virus particle capable of infecting a new target cell. The infectious particle is composed of a host cell‐derived lipid bilayer in which are embedded the viral envelope (Env) glycoprotein spikes (Fig. 1). -
How big is the VPU protein?
This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins. The topology and trafficking of Vpu through subcellular compartments result in pleiotropic effects in host cells. -
What is the full name of the VPR gene?
The vpr gene of HIV-1 encodes a 96-amino-acid 14-kDa protein (viral protein R [Vpr]), which is produced late in the viral life cycle and is incorporated into the virion through an interaction with the p6 region of Gag (36, 38, 46, 53). -
How big is the VPU protein?
This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins. The topology and trafficking of Vpu through subcellular compartments result in pleiotropic effects in host cells. -
What is the full form of VPU gene?
The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release. Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes. -
What is the function of the VpR protein?
VpR is required for efficient viral replication in nondividing cells such as macrophages, and it promotes, to some extent, viral replication in the proliferating target CD4+ T cells. A number of specific activities that may contribute to these effects of VpR have been proposed. -
What is the full name of the VPU gene?
Vpu is an accessory protein that in HIV is encoded by the vpu gene. Vpu stands for "Viral Protein U". The Vpu protein acts in the degradation of CD4 in the endoplasmic reticulum and in the enhancement of virion release from the plasma membrane of infected cells.
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