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The High Mobility Group Protein HMG IY Can Stimulate or Inhibit Pnas Form
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People also ask
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What does HMG stand for in biology?
Thus, it can be expected that the high mobility group (HMG) superfamily of chromatin binding proteins, which have been shown to affect the structure and activity of the chromatin fiber, would affect development and tumorigenesis. -
What is the function of the HMG box?
HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. -
What is the HMG domain protein?
The high-mobility group (HMG) domain is a DNA-binding motif that is shared abundant non-histone components of chromatin and by specific regulators of transcription and cell differentiation. -
What do high mobility group proteins do?
High mobility group (HMG) proteins assume important roles in regulating chromatin dynamics, transcriptional activities of genes and other cellular processes. Post-translational modifications of HMG proteins can alter their interactions with DNA and proteins, and consequently, affect their biological activities. -
What is the function of the HMG protein?
The HMG (high mobility group) proteins are transcription regulators. HMGAs bind to the AT-rich regions of the minor groove of the DNA. HMGA2 is overexpressed in some cancers. It regulates the cell cycle, activates epithelial mesenchymal transition (EMT) and promotes cancer invasion and metastasis. -
What are the HMG chromosomal proteins?
The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the chromatin fiber.
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