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Syndromic Test Case SS31 Form
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People also ask
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What are the side effects of SS-31?
In clinical studies, the main adverse effects associated with SS-31 were found to be injection site adverse reactions, such as erythema (57%), pruritus (47%), pain (20%), urticaria (20%), and irritation (10%), most of which were mild.
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What are the benefits of SS-31?
Neuroprotective Benefit: In models of cognitive impairment, SS-31 improves cognitive functions by promoting mitochondrial and synaptic health and decreasing inflammation and pyroptosis.
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What does SS-31 do?
SS-31 can directly decrease the ROS content, restore the activity of superoxide dismutase (SOD), and decrease the level of malondialdehyde (MDA) and the release of cytochrome c, thus attenuating neurological deficits, brain water content, DNA damage, and neural apoptosis.
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What are the beneficial effects of SS-31 peptide on cardiac mitochondrial dysfunction in Tafazzin knockdown mice?
In conclusion, the SS-31 peptide is able to counteract the mitophagy block in tafazzin-deficient heart restoring the mitochondrial functions towards a potential amelioration of cardiomyopathy in BTHS.
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What are the side effects of SS-31?
In clinical studies, the main adverse effects associated with SS-31 were found to be injection site adverse reactions, such as erythema (57%), pruritus (47%), pain (20%), urticaria (20%), and irritation (10%), most of which were mild.
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What are the benefits of Elamipretide?
This elamipretide-cardiolipin association has been shown to normalize the structure of the inner mitochondrial membrane, thereby improving mitochondrial function. Functional benefit is achieved through improvement of ATP production and interruption and potential reversal of damaging oxidative stress.
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What are peptides for mitochondrial function?
Mitochondrial-derived peptides are encoded by mitochondrial DNA but have biological activity outside mitochondria. Eight of these are encoded by sequences within the mitochondrial 12S and 16S ribosomal genes: humanin, MOTS-c, and the six SHLP peptides, SHLP1-SHLP6.
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