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Tyrosine Kinase Receptor RON Functions Downstream of the Blood Bloodjournal Hematologylibrary Form

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- [Instructor] Over the last couple of videos, we've introduced the idea of signaling and receptors. And we explored in pretty good detail G protein-coupled receptors. In this video, we're gonna explore receptor tyrosine kinases, which we abbreviate RTK. So, in general, receptor tyrosine kinase are really similar to G protein-coupled receptors in the sense that they're receptors present on the outside of cells that respond to some sort of extracellular signal. Okay, right, so our signal, again, interacts with the receptor itself. It makes a very highly specific and high-affinity interaction. And this is then communicated inside of the cell. And that's where the similarities stop. So, receptor tyrosine kinases have the receptor domain itself, the transmembrane domain. And then on the inside of the cell, they have two domains called protein tyrosine kinase domains. So these are PTK domains. So this is a protein, and then the TK are still tyrosine kinase. S

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