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Tyrosine Kinase Receptor RON Functions Downstream of the Blood Bloodjournal Hematologylibrary Form
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People also ask
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What happens when kinase is activated?
Activation of the kinase catalytic domain, which commonly occurs through phosphorylation of the activation loop, results in a conformational change that reorients the catalytic center and thereby allows phosphate transfer from ATP to substrate.
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What is the function of the RTKs?
Receptor tyrosine kinases (RTKs) are a subclass of tyrosine kinases that are involved in mediating cell-to-cell communication and controlling a wide range of complex biological functions, including cell growth, motility, differentiation, and metabolism.
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What happens when RTKs are activated?
Ultimately, RTK activation brings about changes in gene transcription. Signaling becomes complex as signals travel from the membrane to the nucleus, due to crosstalk between intermediates in various signaling pathways in the cell (Figure 1).
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Which of the following occurs when a RTK pathway is activated?
Activation of RTKs results in phosphorylation of additional sites in the cytoplasmic part of the receptor, leading to docking of protein substrates, which initiates the intracellular signaling cascade.
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What happens when tyrosine-kinase is activated?
There are several mechanisms by which tyrosine kinase might acquire transforming functions, but the ultimate result is the constitutive activation of normally controlled pathways leading to the activation of other signaling proteins and secondary messengers which serves to hamper the regulatory functions in cellular ...
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What is the function of a tyrosine receptor kinase?
Receptor tyrosine kinases (RTKs) are a subclass of tyrosine kinases that are involved in mediating cell-to-cell communication and controlling a wide range of complex biological functions, including cell growth, motility, differentiation, and metabolism.
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What is the benefit of using a tyrosine kinase receptor?
Tyrosine kinase inhibitors are targeted therapies for cancer and other conditions. Like all targeted therapies, its major benefit is killing cancer cells without damaging healthy cells. Tyrosine kinase inhibitors may be an alternative when other cancer treatments aren't effective.
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What is the role of ATP in a receptor tyrosine kinase?
Receptor tyrosine kinases (RTKs) are signaling enzymes responsible for the transfer of Adenosine triphosphate (ATP) γ-phosphate to the tyrosine residues substrates. RTKs demonstrate essential roles in cellular growth, metabolism, differentiation, and motility.
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