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 Elelyso Taliglucerase Alfa Medication Precertification Request 2020

Aetna Viscosupplementation 2020-2025 Form

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the genetic test looking for the mutations can define who the carrier state is it's yet to be determined whether the enzymatic state will mimic the genetic state but once a diagnosis is made within the family then the genetics can be assessed subsequently can you will the genetics supersede the enzymatic which will supersede the phenotypic in other words will the genetics be the gold standard and screening and I thurs now and I can give many reasons but the effectiveness of the expression of the enzyme can actually dramatically change depending on the genetics no matter what they are so my guess is uh net to be diagnosed and assessed would be patients with normal genetics yet epigenetic effects on this enzyme in other words diminished production of the enzyme with a normal gene and those populations I think will be found with these screenings that we have for spleen enlargement or something of that nature so genetics I think we'll define carrier state but will not defin

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