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 Ca Form 588 2020

2020-2025 Form

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um I would like to start by thanking the organizers for giving me the opportunity to participate in this very exciting Workshop as we strive to understand the complexity of neurological diseases it becomes increasingly clear that we cannot study the brain or uh develop effective treatments for disease uh by only looking in neurona and not focusing on the extracellular environment and how it changes during neurologic disase and one of the major constituents of the of the extracellular environment of the brain is the brain vasculature what you can see here is a three-dimensional imun labeling of brain vasculature in a cleared Mouse brain and you can see the areas here of the cortex large uh cortical volume as well as the hippocampus and with this advance of uh Imaging we're now able to look at obtain molecular information of the vasculature uh in this uh large large and visualize them in these large uh volumes of course in neurologic disease one of the key changes in the brain va

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