Case Definitions for Form

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chocolate case definitions are a set of rules that allow investigators and clinicians to determine who has and who has not an illness they are a foundation for studying any illness like a deck of cards they are at the bottom level that must be sturdy this is an example of what a case definition should look like it should have a sturdy foundation so the top can be more sturdy if there are ambiguities with case definitions samples of patients will be different on fundamental aspects of an illness resulting in difficulties replicating findings across different labs estimating the prevalence of the illness consistently identifying biomarkers and determining which treatments help patients the nature of the problem before us is that there are currently multiple case definitions cfs mecfs me scid each has different criteria and different names over 20 have been developed but are rarely guided by the scientific method our challenge is to decide in which case definitions for clinical and resear