Definition List for Drug Safety Form

Instructions and help about Definition List For Drug Safety

today's pharmaco topic is drug safety drugs approved by the FDA must be shown to be safe and effective most adverse effects of drugs are dose dependent meaning the higher the dose the worse the adverse effect becomes therapeutic index is the relationship between safety and Effectiveness and is determined by dividing the toxic dose by the effective dose the toxic dose or td50 is the amount that is toxic in 50 percent of a population and is divided by ed50 which is the therapeutic dose or the dose that is effective for the desired response in 50 percent of a population higher therapeutic index values represent a relatively safer drug or a bigger difference between toxic and effective doses for example the td50 of a drug is one thousand milligrams and the ed50 is 10 milligrams the therapeutic index would be 100 and would be a relatively safe drug in contrast dangerous drugs have a low therapeutic index because toxic and effective doses are more similar for example if the td50 of a drug wa