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COMMON STOCK PURCHASE AGREEMENT COMMON STOCK PURCHASE AGREEMENT (this "Agreement") dated as of December 14, 1999, by and among IMMUNOMEDICS, INC., a Delaware corporation (the "Company"), and the PURCHASERS listed on Exhibit A ("Purchasers"). The Company desires to issue and sell to Purchasers, and Purchasers desire to purchase from the Company, shares (the "Common Shares") of the Company's common stock, par value $.01 per share (the "Common Stock"), at $3.00 per share (the "Per Share Price") upon and subject to the terms and conditions of this Agreement. Accordingly, in consideration of the premises and the mutual agreements contained herein, and for other good and valuable consideration, Purchasers and the Company agree as follows: 1. Purchase of Company Securities. 1.1. Purchase and Sale of the Common Shares. (a) Subject to the terms and conditions of this Agreement, (i) the Company shall issue and sell to Purchasers, and Purchasers, severally and not jointly, shall purchase from the Company, 2,500,000 shares of Common Stock as set forth on Exhibit A (allocated among the Purchasers as set forth on Exhibit A). Such shares of Common Stock are hereinafter sometimes referred to as the "Securities." The aggregate purchase price for the Common Shares shall be $7,500,000 (the "Aggregate Purchase Price") (allocated among the Purchasers as set forth on Exhibit A). 2. Closing. 2.1. Closing. The closing of the purchase and sale of the Common Shares shall take place at a single closing at the offices of Paramount Capital Asset Management, Inc. ("Paramount"), at 787 Seventh Avenue, 48th Floor, New York, New York, 10019. Such closing (the "Closing") will take place contemporaneously with the execution and delivery of this Agreement. The date of the Closing is referred to as the "Closing Date." At the Closing, the Company will deliver to Purchasers the Common Shares against payment of the Aggregate Purchase Price by Purchasers by wire transfer payable to the Company pursuant to the instructions attached hereto as Exhibit B. The Common Shares shall be registered in Purchasers' names in such denominations as are set forth on Exhibit A annexed hereto. 3. Conditions to the Obligations of Purchasers at the Closing. The obligation of Purchasers to purchase and pay for the Common Shares to be purchased by Purchasers at the Closing is subject to the satisfaction on or prior to the Closing Date of the following conditions, which may only be waived by written consent of Purchasers: 3.1. Opinion of Counsel to the Company. Purchasers shall have received from Lowenstein Sandler PC, counsel for the Company, its opinion dated the Closing Date in the form of Exhibit C. 3.2. Representations and Warranties. All of the representations and warranties of the Company contained in this Agreement shall be true and correct at and as of the Closing Date. 3.3. Performance of Covenants. All of the covenants and agreements of the Company contained in this Agreement required to be performed on or prior to the Closing Date shall have been performed in a manner satisfactory in all respects to Purchasers. 3.4. Legal Action. No injunction, order, investigation, claim, action or proceeding before any court or governmental body shall be pending or threatened wherein an unfavorable judgment, decree or order would restrain, impair or prevent the carrying out of this Agreement or any of the transactions contemplated thereby, declare unlawful the transactions contemplated by this Agreement or cause any such transaction to be rescinded. 3.5. Consents. The Company shall have obtained in writing or made all consents, waivers, approvals, orders, permits, licenses and authorizations of, and registrations, declarations, notices to and filings and applications with, any governmental authority or any other Person (including, without limitation, securityholders and creditors of the Company) required to be obtained or made in order to enable the Company to observe and comply with all of its obligations under this Agreement and to consummate and perform the transactions contemplated hereby. The Board of Directors of the Company shall have taken all action required to permit the transactions contemplated by this Agreement. 3.6. Closing Documents. The Company shall have delivered to Purchasers the following: (a) a certificate executed on behalf of the Company by the Chairman and Chief Executive Officer of the Company dated the Closing Date stating that the conditions set forth in Sections 3.2 through 3.5 have been satisfied; (b) a certificate of the Secretary of the Company, dated the Closing Date, as to the continued and valid existence of the Company, certifying the attached copy of the By-laws of the Company, the authorization of the execution, delivery and performance of this Agreement, and the resolutions adopted by the Board of Directors of the Company authorizing the actions to be taken by the Company under this Agreement; (c) a certificate of the Secretary of State of the State of Delaware, dated a recent date, to the effect that the Company is in good standing in the State of Delaware and that all annual reports, if any, have been filed as required and, if readily available that all franchise taxes and fees have been paid in connection therewith; (d) a certified copy of the Certificate of Incorporation of the Company as filed with the Secretary of State of the State of Delaware, including any amendments thereto; and 2 (e) such certificates, other documents and instruments as Purchasers and their counsel may reasonably request in connection with, and to effect, the transactions contemplated by this Agreement. 3.7. Proceedings. All corporate and other proceedings taken or to be taken in connection with the transactions contemplated by this Agreement to be consummated at such Closing and all documents incident thereto shall be satisfactory in form and substance to Purchasers. 3.8. Closing Financial Statements; Absence of Changes. (a) The Company shall have provided to Purchasers (i) the unaudited balance sheets of the Company as of September 30, 1999, and the related unaudited statements of operations, and cash flows for the three-month period then ended (the "Financial Statements"), all of which will be correct and complete and will present fairly the financial position of the Company and the results of its operations and cash flows as of the time and for the periods then ended, provided adjusting and closing entries ordinarily made at the close of any such period in connection with audit, and footnote information, are omitted, and (ii) the unqualified certification, in form and substance satisfactory to Purchasers, of the Chief Financial Officer of the Company, acting on behalf of the Company, to the effect that the Financial Statements have been prepared in accordance with the books and records of the Company and generally accepted accounting principles applied on a basis consistent with prior years (except as otherwise specified in such certification), and present fairly the financial position of the Company and the results of its operations cash flows as of the time and for the periods then ended, provided adjusting and closing entries ordinarily made at the close of any such period in connection with audit, and footnote information, are omitted. (b) Except as set forth on the schedules to this Agreement or as previously publicly disclosed, and except for net losses consistent in scope with net losses incurred by the Company during the nine months ended September 30, 1999, there shall have been no material adverse change in the business, financial condition, operating results, employee or customer relations or prospects of the Company, from September 30, 1999 to the Closing Date. 3.9. Schedules. The Company shall have provided to Purchasers all schedules required pursuant to this Agreement, which schedules shall be satisfactory to Purchasers in their sole discretion. 3.10. Material Agreements. The Company shall have provided to the Purchasers a copy of agreements entered by and among the Company and all holders of its Series F Convertible Preferred Stock pursuant to which such holders have agreed that the Company may redeem all outstanding shares of Series F Preferred Stock at any time on or before December 31, 1999, at a price equal to 109% of the stated value of such Series F Convertible Preferred Stock (which is $10,000). 4. Conditions to the Obligations of the Company at the Closings. The obligation of the Company to issue and sell the Common Shares to the Purchasers at the Closing is subject to the satisfaction on or prior to the Closing Date of the following conditions, any of which may be waived by the Company: 3 4.1. Representations and Warranties. The representations and warranties of Purchasers contained in this Agreement shall be true and correct at and as of the Closing Date. 4.2. Legal Action. No injunction, order, investigation, claim, action or proceeding before any court or governmental body shall be pending or threatened wherein an unfavorable judgment, decree or order would restrain, impair or prevent the carrying out of this Agreement or any of the transactions contemplated hereby, declare unlawful the transactions contemplated hereby or cause any such transaction to be rescinded. 4.3 Performance of Covenants. All of the covenants and agreements of the Purchasers contained in this Agreement required to be performed on or prior to the Closing Date shall have been performed in a manner satisfactory in all respects to the Company. 5. Representations and Warranties of the Company. The representations and warranties of the Company contained herein are subject to and qualified by the disclosures made in the Company's most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q, as filed with the SEC. The Company hereby represents and warrants to each Purchaser as of the Closing Date as follows: 5.1. Organization. The Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware. The Company is eligible to be treated as a C corporation under the Internal Revenue Code of 1986, as amended (the "Code"). The Company has all requisite corporate power and authority, and holds all licenses, permits and other required authorizations from governmental authorities, necessary to conduct its business as now being conducted and to own or lease the properties and assets now owned or held under license or lease. The Company is duly qualified or licensed and in good standing as a foreign corporation in each jurisdiction wherein the character of its properties or the nature of the activities conducted by it makes such qualification or licensing necessary, except where the failure to so qualify would not have a material adverse effect on the Company. 5.2. Charter Documents. The Company has heretofore delivered to Purchasers true, correct and complete copies of the Certificate of Incorporation and By-Laws (or comparable organizational documents) of the Company as in full force and effect on the date hereof. 5.3. Capitalization. As of December 10, 1999, the Company's authorized capitalization consists of 70,000,000 shares of Common Stock, of which 43,655,709 shares are issued and outstanding, and 10,000,000 shares of preferred stock, par value $.01 per share, of which 595.5 shares are designated as Series F Convertible Preferred Stock and are issued and outstanding. 15,022,288 shares of Common Stock are reserved for issuance upon the conversion or exercise of convertible securities, options, warrants or other rights to purchase Common Stock outstanding as of the Closing Date. All outstanding securities of the Company are validly issued, fully paid and nonassessable. Except for the rights of the Series F Convertible Preferred Stock, no stockholder of the Company is entitled to any preemptive rights with respect to the purchase or sale of any securities by the Company. There are no outstanding options, warrants or other rights, commitments or arrangements, written or oral, to purchase or otherwise acquire any authorized but unissued shares of capital stock of the Company or any security directly or indirectly convertible into or exchangeable for any capital stock of the Company or under which any such option, warrant or convertible security may be issued in the future except otherwise as set forth on Schedule 5.3. There are no voting trusts or agreements, stockholders' agreements, pledge agreements, buy-sell, rights of 4 first offer, negotiation or refusal or proxies or similar arrangements relating to any securities of the Company to which the Company is a party, and to the best knowledge of the Company after due inquiry there are no other such trusts, agreement, rights, proxies or similar arrangements, except as set forth on Schedule 5.3. Except as otherwise set forth on Schedule 5.3 or as contemplated by this Agreement, none of the shares of capital stock of the Company is reserved for any purpose, and the Company is neither subject to any obligation (contingent or otherwise), nor has any option to repurchase or otherwise acquire or retire any shares of its capital stock. 5.4 Due Authorization, Valid Issuance, Etc. The Common Shares to be purchased on the Closing Date have been duly authorized and, when issued in accordance with this Agreement upon the Closing Date, will be validly issued, fully paid and non-assessable and will be free and clear of all liens imposed by or through the Company, subject only to restrictions set forth herein, as applicable, or applicable federal and state securities laws. The issuance, sale and clear delivery of such Common Shares will not be subject to any preemptive right of stockholders of the Company or to any right of first refusal or other right in favor of any person or entity except for provisions which have been waived in writing (and as to which the Purchasers have received a copy of) or satisfied and as set forth on Schedule 5.4. The Company's executive officers and directors have studied and fully understand the nature of the securities being sold hereunder, and recognize that they have a potential dilutive effect. Except as set forth on Schedule 5.4, no anti-dilution adjustments with respect to the outstanding securities of the Company will be triggered by the issuance of the securities contemplated hereby. 5.5. Subsidiaries. Except as otherwise disclosed in the Company's Annual Report on Form 10-K for the year ended June 30, 1999, the Company has no wholly or partially owned Subsidiaries (as defined in Section 9.9) and does not control, directly or indirectly, any other corporation, business trust, firm, partnership, association, joint venture, entity or organization. Except as otherwise disclosed in the Company's Annual Report on Form 10-K for the year ended June 30, 1999, the Company does not own any shares of stock, partnership interest, joint venture interest or any other security, equity or interest in any other corporation or other Person. 5.6. Authorization; No Breach. The Company has the full corporate power and authority to execute, deliver and enter into this Agreement and to perform its obligations hereunder, and the execution, delivery and performance of this Agreement and all other transactions contemplated hereby have been duly authorized by the Company. This Agreement constitutes a legal, valid and binding obligation of the Company, enforceable in accordance with its terms except as such enforceability may be limited by (a) bankruptcy, insolvency, moratorium and similar laws affecting creditors' rights generally and (b) the availability of remedies under general equitable principles. Except 5 as set forth on Schedule 5.6, the execution and delivery by the Company of this Agreement, the offering, sale and issuance of the Common Shares, and the performance and fulfillment by the Company of its obligations hereunder, do not and will not (i) conflict with or result in a breach of the terms, conditions or provisions of, (ii) constitute a default under, or event which, with notice or lapse of time or both, would constitute a breach of or default under, (iii) result in the creation of any lien, security interest, adverse claim, charge or encumbrance upon the capital stock or assets of the Company pursuant to, (iv) give any third party the right to accelerate any obligation under or terminate, (v) result in a violation of, (vi) result in the loss of any license, certificate, legal privilege or legal right enjoyed or possessed by the Company under, or (vii) with the exception of an application to NASDAQ, require any authorization, consent, approval, exemption or other action by or notice to any court or administrative or governmental body pursuant to or require the consent of any other Person under, the Certificate of Incorporation or By-Laws of the Company or any law, statute, rule or regulation to which the Company is subject or by which any of its properties are bound, or any agreement, instrument, order, judgment or decree to which the Company is subject or by which its properties are bound, except, in all instances, for matters which do not materially adversely affect the Company's business, financial condition, result of operations or prospects ("Material Adverse Effect"). 5.7. No Material Adverse Changes. Since September 30, 1999, except as disclosed on Schedule 5.7 there has not at any time been any material adverse change in the business, financial condition, operating results, business prospects, employee relations or customer relations of the Company. Except as set forth on Schedule 5.7, no event or circumstance has occurred or exists with respect to the Company or its business, properties, prospects, operations or financial condition, which, under applicable law, rule or regulation, requires public disclosure or announcement by the Company but which has not been so publicly announced or disclosed. 5.8. Absence of Certain Developments. Except as contemplated by this Agreement, and except as set forth on Schedule 5.8, since September 30, 1999 the Company has not, nor will have prior to the Closing Date: (a) issued any securities (other than as permitted or contemplated by this Agreement or securities issued subsequent to December 10, 1999 upon conversion of outstanding securities or options); (b) borrowed any amount or incurred or became subject to any liabilities (absolute or contingent) which involve $50,000 or more, other than liabilities incurred in the ordinary course of business and liabilities under contracts entered into in the ordinary course of business; (c) discharged or satisfied any lien, adverse claim or encumbrance or paid any obligation or liability (absolute or contingent), other than current liabilities paid in the ordinary course of business; (d) declared or made any payment or distribution of cash or other property to the stockholders of the Company with respect to the Common Stock or purchased or redeemed any shares of Common Stock; (e) mortgaged, pledged or subjected to any lien, adverse claim, charge or any other encumbrance, any of its properties or assets, except for liens for taxes not yet due and payable and transactions in the ordinary course of business; (f) sold, assigned or transferred any of its assets, tangible or intangible, except in the ordinary course of business or in an amount less than $50,000, or disclosed to any person, firm or entity not subject to a confidentiality obligation with the Company any proprietary confidential information; (g) suffered any extraordinary losses or waived any rights of material value; (h) made any capital expenditures or commitments therefor greater than $50,000 in the aggregate; (i) entered into any other transaction other than in the ordinary course of business; (j) made any charitable contributions or pledges; (k) suffered damages, destruction or casualty loss, whether or not covered by insurance, affecting any of the 6 properties or assets of the Company or any other properties or assets of the Company which could have a material adverse effect on the business, financial condition, operating results, employee or customer relations or prospects of the Company; (l) made any material change in the nature or operations of the business of the Company; or (m) resolved to or entered into any agreement or understanding with respect to any of the foregoing. 5.9. Properties. The Company has good and marketable title to all of the real property and good title to all of the personal property and assets it purports to own as set forth in the Financial Statements, whether such property is real or personal, free and clear of all liens, adverse claims, charges, encumbrances or restrictions of any nature whatsoever, except (a) such as are reflected on Schedule 5.9 or in the notes to the Financial Statements in the Company's Annual Report on Form 10-K for the year ended June 30, 1999, (b) for receivables and charges collected in the ordinary course of business, (c) liens with respect to taxes not yet due and (d) immaterial exceptions of a routine and customary nature. Except as disclosed in Schedule 5.9, the Company owns or leases all such properties as are necessary to its operations as now conducted and as presently proposed to be conducted and all such properties are, in all material respects, in good operating condition and repair. 5.10. Taxes. Except as set forth on Schedule 5.10, the Company has timely filed all federal, state, local and foreign tax returns and reports required to be filed, and all taxes, fees, assessments and governmental charges of any nature shown by such returns and reports to be due and payable have been timely paid except for those amounts being contested in good faith and for which appropriate amounts have been reserved in accordance with generally accepted accounting principles. There is no tax deficiency that has been, or, to the best knowledge of the Company after due inquiry may reasonably be, asserted against the Company that would materially adversely affect the business or operations, or proposed business or operations, of the Company. All such tax returns and reports were prepared in accordance with the relevant rules and regulations of each taxing authority having jurisdiction over the Company and are true and correct in all material respects. The Company has neither given nor been requested to give any waiver of any statute of limitations relating to the payment of federal, state, local or foreign taxes. The Company has not been, nor, to its knowledge, is it now being, audited by any federal, state, local or foreign tax authorities. The Company has made all required deposits for taxes applicable to the current tax year. The Company is not, and has never been, a member of any "affiliated group" within the meaning of Section 1504 of the Code, as in effect from time to time. 5.11. Litigation. Except as set forth on Schedule 5.11, there are no actions, suits, proceedings, orders, investigations or claims pending or, to the best knowledge of the Company after due inquiry, threatened against or affecting the Company, at law or in equity or before or by any federal, state, municipal or other governmental department, commission, board, bureau, agency or instrumentality; there are no arbitration proceedings pending under collective bargaining agreements or otherwise. 5.12. Compliance with Law. The Company has complied in all material respects with all applicable statutes and regulations of the United States and of all states, municipalities and applicable agencies and foreign jurisdictions or bodies in respect of the conduct of its business and operations. 7 5.13. Trademarks and Patents. Schedule 5.13 contains a true, complete and correct list of all registered, certificated or issued trademarks, trade names, patents and copyrights (and applications therefor), if any, owned or (to the extent evidenced by contract or license agreement) licensed or used or required to be used by the Company as of or prior to the Closing Date in connection with its business and, except as set forth on Schedule 5.13, each such trademark, trade name, patent and copyright (and application therefor) listed in Schedule 5.13 as being owned by the Company is not subject to any license, royalty arrangement, option or dispute and is free and clear of all material liens. To the best knowledge of the Company after due inquiry, none of the trademarks, trade names, patents or copyrights used by the Company in connection with its business infringes any trademark, trade name, patent or copyright of others in the United States or in any other country, in any way which materially adversely affects or which in the future is reasonable likely to materially adversely affect the business or operations of the Company. Except as set forth on Schedule 5.13 or in the Company's Annual Report on Form 10-K for the year ended June 30, 1999, no stockholder, officer or director of the Company or any other person owns or has any interest in any trademark, trade name, service mark, patent, copyright or application therefor, or trade secret, licenses, invention, information or proprietary right or process, if any, used by the Company in connection with its business. The Company has no notice or knowledge of any objection or claim being asserted by any person with respect to the ownership, validity, enforceability or use of any such trademarks, trade names, patents and copyrights (and applications therefor) listed on Schedule 5.13 or challenging or questioning the validity or effectiveness of any license relating thereto. There are no unresolved conflicts with, or pending claims of, any other person, whether in litigation or otherwise, involving the trademarks, trade names, patents and copyrights (and applications therefor), and there are no liens, encumbrances, adverse claims, or rights of any other person which would prevent the Company from fulfilling its obligations under this Agreement except in all cases which would not have a Material Adverse Effect. To the best knowledge of the Company after due inquiry, the business of the Company, as presently conducted does not cause the Company to violate any trademark, trade name, patent, copyright, trade secret, license or proprietary interest of any other person or entity, in any way which materially adversely affects the business or operations of the Company. Except as disclosed in Schedule 5.13, the Company possesses all proprietary technology necessary for the conduct of its business. 5.14. Insurance. Each of the Company's insurance policies is in full force and effect; and the Company is not in default in any material respect with respect to its obligations under any of such insurance policies. Such insurance coverage is in amounts not less than is customarily maintained by corporations engaged in the same or similar business and similarly situated, including, without limitation, insurance against loss, damage, fire, theft, public liability and other risks. The activities and operations of the Company have been conducted in a manner so as to conform to all applicable provisions of these insurance policies and the Company has not taken or failed to take any action which would cause any such insurance policy to lapse. 5.15. Agreements. Except as set forth on Schedule 5.15 or as disclosed in the Company's proxy statement for its 1999 annual meeting of stockholders or as filed on the Company's most recent Annual Report on Form 10-K, the Company is not party to nor bound by any agreement or commitment, written or oral, which obligates the Company to make payments to any person, or which obligates any person to make payments to the Company, in the case of each such agreement in an amount exceeding $60,000, or which is otherwise material to the conduct and operation of the business of the Company or any of its 8 properties or assets, including, without limitation, all shareholder, employment, non-competition and consulting agreements and employee benefit plans and arrangements and collective bargaining agreements to which the Company is a party or by which it is bound. The Company has performed all material obligations required to be performed by it, and is not in default, or in receipt of any claim, under any such agreement or commitment, and the Company has no present expectation or intention of not fully performing all of such obligations, nor does the Company have any knowledge of any breach or anticipated breach by the other parties to any such agreement or commitment. Each Purchaser has been furnished with, or the Company has made available for such Purchaser's review, a true and correct copy of each written agreement referred to in Schedule 5.15, together with all amendments, waivers or other changes thereto. 5.16. Undisclosed Liabilities. Except to the extent reflected, disclosed or reserved against in the Financial Statements or the notes thereto and except for liabilities incurred since September 30, 1999 in the ordinary course and consistent with past practice, the Company does not have any obligation or liability whether absolute, accrued, contingent or otherwise, which is material to the business, operations, assets or financial condition of the Company. 5.17. Employees; Conflicting Agreements. (a) The Company has caused all present members of management and all professional employees of and consultants and advisors to the Company, including all employees and consultants and advisors involved in research and development, and will cause all such persons in the future, to be subject to agreements with respect to (i) nondisclosure of confidential information, (ii) assignment of patents, trademarks, copyrights and proprietary rights to the Company and (iii) disclosure to the Company of inventions. (b) To the best knowledge of the Company after due inquiry, no stockholder, director, officer or key employee of the Company is a party to or bound by any agreement, contract or commitment, or subject to any restrictions in connection with any previous or current employment of any such person (other than as set forth on Schedule 5.17(b) with respect to the Company), which materially adversely affects, or which in the future may materially adversely affect, the business or the proposed business of the Company or the rights of any of the Purchasers under this Agreement. 5.18. Disclosure. Neither this Agreement nor any of the schedules, exhibits, written statements, documents or certificates prepared or supplied by the Company with respect to the transactions contemplated by this Agreement contain any untrue statement of a material fact or omit a material fact necessary to make the statements contained therein not misleading in light of the circumstances under which made. Except for general factors that are common in the market and industry of the Company and such other information made available to the Purchasers and their representatives, there exists no fact or circumstance which, to the best knowledge of the Company after due inquiry, materially adversely affects, or which could reasonably be anticipated to have a material adverse effect on, the existing or expected financial condition, operating results, assets, customer relations, employee relations or business prospects of the Company. 9 5.19. Compliance with Securities Laws. (a) Assuming the accuracy and truth of each of Purchasers' representations set forth in Section 6, all securities of the Company heretofore sold and issued were sold and issued, and the Common Shares were offered and will be sold and issued, in compliance with all applicable federal, state and foreign securities laws. Neither the Company, nor any of its Affiliates, nor, to its best knowledge after due inquiry, any person or entity acting on its or their behalf has, directly or indirectly, made any offers or sales of any security or solicited any offers to buy any security, under circumstances that would require registration of the Common Shares under the Securities Act of 1933, as amended (the "Securities Act") or for the offering of the same to be integrated with any other offering of securities. (b) The Company has not directly or indirectly purchased or redeemed any shares of Common Stock during the 30 days preceding the Closing Date. 5.20. Brokers. Except as set forth on Schedule 5.20, no finder, broker, agent, financial person or other intermediary has acted on behalf of the Company in connection with the offering of the Common Shares, the execution of the Agreement or the consummation of any of the transactions contemplated hereby. 5.21. Transactions with Affiliates. Except as set forth on Schedule 5.21 or in the Company's proxy statement for its 1999 annual meeting of stockholders, no director, officer, employee, consultant or agent of the Company, or member of the family of any such person or any corporation, partnership, trust or other entity in which any such person, or any member of the family of any such person, has a substantial interest in or is an officer, director, trustee, partner or holder of more than 5% of the outstanding capital stock thereof, is a party to any transaction with the Company, including any contract, agreement or other arrangement providing for the employment of, furnishing of services by or requiring payments to any such person or firm. 5.22. Environmental Matters. (a) The Company, and all properties owned, operated or leased by the Company, have obtained and currently maintain all material environmental permits required for their business and operations and are in compliance with all such environmental permits. There are no legal proceedings pending nor, to the best knowledge of the Company after due inquiry, threatened to modify or revoke any such environmental permits. The Company has not received any notice from any source that there is lacking any environmental permit required for the current use or operation of the business of the Company, or any property owned, operated or leased by the Company. (b) Except as set forth on Schedule 5.22, all real property owned, operated or leased by the Company, and, to the best knowledge of the Company after due inquiry, all property adjacent to such properties, are free from contamination by any hazardous material other than any such contamination as would not have a Material Adverse Effect; and the Company is not subject to environmental costs and liabilities with respect to hazardous materials, and no facts or circumstances exist which could give rise to environmental costs and liabilities with respect to hazardous materials. 10 (c) Except as set forth on Schedule 5.22, there is not now, nor, to the best knowledge of the Company after due inquiry, has there been in the past, on, in, or under any real property owned, leased, or operated by the Company, or by any of their respective predecessors (i) any asbestos-containing materials, (ii) any underground storage tanks, (iii) above-ground storage tanks, (iv) impoundments, (v) poly-chlorinated biphenyls or (vi) radioactive substances. (d) The Company, and all properties owned, operated or leased by the Company, comply with all environmental laws. (e) Since June 30, 1998, neither the Company, nor any property owned, leased or operated by the Company, has received or been issued any written request for information, or has been notified that it is a potentially responsible party under the environmental laws with respect to any on-site or off-site for which environmental costs and liabilities are asserted. 6. Representations, Warranties and Covenants of Purchasers. Purchasers severally represent, warrant and covenant to the Company as of the Closing Date as follows: 6.1. Investment Intent. Each Purchaser is an "accredited investor" within the meaning of Regulation D under the Securities Act. Each Purchaser has experience in making investments in development stage biotechnology companies and is acquiring the Common Shares for its own account and not with a present view to, or for sale in connection with, any distribution thereof in violation of the registration requirements of the Securities Act. Each Purchaser consents to the placing of a legend on the certificates representing its respective Common Shares to the effect that, and each Purchaser acknowledges that, such Common Shares have not been registered under the Securities Act and may not be transferred unless registered in accordance with applicable securities laws or, in the opinion of counsel to the Purchasers (such opinion to be in form and substance reasonably satisfactory to the Company), exempt therefrom. 6.2. Authorization. Each Purchaser has the power and authority to execute and deliver this Agreement and to perform its obligations hereunder, having obtained all required consents, if any, and this Agreement, when executed and delivered, will constitute a legal valid and binding obligation of such Purchaser except as such enforceability may be limited by (a) bankruptcy, insolvency, moratorium and similar laws affecting creditors' rights generally and (b) the availability of remedies under general equitable principles. 6.3. Brokers. No finder, broker, agent, financial person or other intermediary has acted on behalf of the Purchasers in connection with the offering of the Common Shares or the consummation of this Agreement or any of the transactions contemplated hereby. 6.4. No Short. For a period of six months from the Closing Date, the Purchasers will not "short" or "short against the box" (as those terms are generally understood) any equity security of the Company; provided, however, that if the Shelf Registration Statement (as defined below) is not effective by the date that is 60 days following the Closing Date, then the Purchasers shall have no obligation under this section 6.4 until such time as the Shelf Registration Statement is declared effective by the SEC. 11 7. Covenants of the Company. Until such time as (a) Purchasers and their Affiliates beneficially own less than five percent (5%) of the Common Stock then outstanding, the Company covenants and agrees with Purchasers as follows: 7.1. Books and Accounts. The Company will: (a) make and keep books, records and accounts, which, in reasonable detail, accurately and fairly reflect its transactions, including without limitation, dispositions of its assets; and (b) devise and maintain a system of internal accounting controls sufficient to provide reasonable assurances that (i) transactions are executed in accordance with management's general or specific authorization, (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with generally accepted accounting principles and in accordance with the Company's past practices or any other criteria applicable to such statements, and to maintain accountability for assets, (iii) access to assets is permitted only in accordance with management's general or specific authorization, and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect to any differences. 7.2. Periodic Reports. The Company will furnish to the Purchasers, other than documents available via EDGAR: (i) as soon as practicable (but in the case of the annual report of the Company to its stockholders, within ninety (90) days after the end of each fiscal year of the Company) one copy of: (A) its annual report to its stockholders (which annual report shall contain financial statements audited in accordance with generally accepted accounting principles in the United States of America by a firm of certified public accountants of recognized standing), (B) if not included in substance in its annual report to stockholders, its annual report on Form 10-K, (C) each of its quarterly reports to its stockholders, and if not included in substance in its quarterly reports to stockholders, its quarterly report on Form 10-Q, (D) each of its current reports on Form 8-K, and (E) a copy of the full Shelf Registration Statement (as defined below), (the foregoing, in each case, excluding exhibits); and (ii) upon reasonable request, all exhibits excluded by the parenthetical to the immediately preceding clause 7.2(a)(i)(E) and any other information published by the Company that is generally available to the public. 7.3. Other Reports and Inspection. The Company will furnish to the Purchasers, other than documents available via EDGAR: (a) as soon as practicable after issuance, copies of any financial statements or reports prepared by the Company for, or otherwise furnished to, its stockholders or the SEC (other than information furnished to the SEC on a confidential or supplemental basis) and (b) promptly, such other documents, reports and financial data as Purchasers may reasonably request, provided that the Purchasers agree to preserve the confidential nature of, and to refrain from trading on the basis of, material requested by the Purchasers which the Company has marked as confidential. In addition the Company will, upon reasonable prior notice, make available to Purchasers or its representatives or designees (x) all assets, properties and non-confidential business records of the Company for inspection and (y) the directors and officers of the Company for interviews concerning the business, affairs and finances of the Company. 12 7.4. Insurance. The Company will at all times maintain valid policies of worker's compensation insurance and such other insurance with respect to its properties and business of the kinds and in amounts not less than is customarily maintained by corporations engaged in the same or similar business and similarly situated, including, without limitation, insurance against fire, loss, damage, theft, public liability and other risks. The activities and operations of the Company shall be conducted in a manner to conform in all material respects to all applicable provisions of such policies. 7.5. Use of Proceeds. The Company shall use the net proceeds from the sale of the Common Shares for the redemption of all outstanding shares of its Series F Convertible Preferred Stock at a price equal to 109% of the stated value of such Series F Convertible Preferred Stock (which is $10,000). Any net proceeds exceeding the amount required to redeem the Series F Convertible Preferred Stock shall be used for general corporate purposes. 7.6. Transactions with Affiliates. Except for employment and consulting agreements entered into in the ordinary course of business (including such agreements in effect as of the Closing Date) and the transactions contemplated by this Agreement, the Company shall not (a) engage in any transaction with, (b) make any loans to, nor (c) enter into any contract, agreement or other arrangement (i) providing for (x) the employment of, (y) the furnishing of services by (other than employment and consulting services), or (z) the rental of real or personal property from, or (ii) otherwise requiring payments to, any officer, director or key employee of the Company or any relative of such persons or any other "associate" of such persons (as such terms are defined in the rules and regulations promulgated under the Securities Act), without the prior written approval of the Purchasers, which approval shall not be unreasonably withheld. 7.7. Corporate Existence, Licenses and Permits; Maintenance of Properties; New Businesses. The Company will at all times conduct its business in the ordinary course and will use its best efforts to cause to be done all things necessary to maintain, preserve and renew its existence and will use its best efforts to preserve and keep in force and effect, all licenses, permits and authorizations necessary to the conduct of its business. The Company will also maintain and keep its properties in good repair, working order and condition, and from time to time, to make all needful and proper repairs, renewals and replacements, so that the business carried on in connection therewith may be properly conducted at all times. 7.8. Other Material Obligations. The Company will use its best efforts to comply in all material respects with, (a) all material obligations which it is subject to, or becomes subject to, pursuant to any contract or agreement, whether oral or written, as such obligations are required to be observed or performed, unless and to the extent that the same are being contested in good faith and by appropriate proceedings and the Company has set aside on its books adequate reserves with respect thereto, and (b) all applicable laws, rules, and regulations of all governmental authorities, the violation of which could have a material adverse effect upon the business, financial condition, operating results, employee or customer relations or prospects of the Company. 13 7.9. Amendment to the Certificate of Incorporation and the By-Laws. The Company will perform and be in compliance with and observe all of the provisions set forth in its Certificate of Incorporation and By-Laws to the extent that the performance of such obligations is legally permissible; provided that the fact that performance is not legally permissible will not prevent such nonperformance from constituting an event of default under this Agreement. Except with the consent of the Purchasers, which consent shall not be unreasonably withheld, the Company will not amend its Certificate of Incorporation or By-Laws or any Certificate of Designations for any series of Preferred Stock of the Company so as to affect adversely the rights of Purchasers under this Agreement, the Certificate of Incorporation or the By-Laws. 7.10. Consents and Waivers. The Company has obtained all consents and waivers needed to enable it to perform all of its obligations under this Agreement and the transactions contemplated hereby. 7.11. Taxes and Liens. The Company shall duly pay and discharge when payable, all taxes, assessments and governmental charges imposed upon or against the Company or its properties, or any part thereof or upon the income or profits therefrom, in each case before the same become delinquent and before penalties accrue thereon, as well as all claims for labor, materials or supplies which if unpaid might by law become a lien upon any of its property, unless and to the extent that the same are being contested in good faith and by appropriate proceedings and the Company has set aside on its books adequate reserves with respect thereto. 7.12. Restrictive Agreement. The Company covenants and agrees that subsequent to the Closing, it shall not be a party to any agreement or instrument which by its terms would restrict the Company's performance of its obligations pursuant to this Agreement, the Certificate of Incorporation or By-laws of the Company or the Common Shares. 7.13. Publicity. The Company shall not issue any press release or make any other public announcement with respect to this Agreement or the transactions contemplated hereby or utilizing the names of Purchasers or their officers, directors, employees, agents or Affiliates without obtaining the prior approval of Purchasers, except as may be required by law or the regulations of any securities exchange. 7.14. Restriction on Securities. (a) During the 12-month period following the Closing Date, the Company will not extend the expiration date or lower the exercise price of any options or warrants, or take any similar action with respect to any convertible securities of the Company. (b) Prior to the Closing Date, the Company shall obtain the written agreement of all executive officers and directors of the Company to (i) "lock-up" all of the shares of Common Stock owned by each of them at any time until (1) the date on which all Common Shares may be sold in a single transaction on a registered securities exchange or national market under an applicable exemption from the registration requirements of the Securities Act and all other applicable securities laws and (2) the date that is six months 14 following the Closing Date; provided that the executive officers and directors of the Company may sell an aggregate of one million (1,000,000) shares of Common Stock in such 6-month period so long as any such executive officer or director provide to the Purchasers a written notice of their intent to sell at least five (5) days prior to the earlier of (A) the filing of a Form 144 by such person and (B) the date of such proposed sale, (ii) not directly or indirectly sell "short" or "short against the box" (as those terms are generally understood), until the date that is 6 months following the Closing Date. 7.15. Restriction on Liens. The Company shall not create or permit the imposition of any liens on any of its assets from and after the Closing Date without the prior written authorization of the Board of Directors. 7.16. Restrictions on Indebtedness. Without the prior approval of the Board of Directors, the Company shall not incur, create, assume or permit to exist any indebtedness except (i) pursuant to equipment lease financings with commercial banks or Persons whose business consists in substantial part of engaging in such financings, (ii) pursuant to customary accounts receivable and inventory financing in the ordinary course of business, (iii) in an amount less than $100,000 incurred in the ordinary course of business, and (iv) indebtedness for borrowed money existing on the date hereof and disclosed in writing to the Purchasers, but not any extensions, renewals or replacements of such indebtedness. 7.17. Board of Directors. (a) The Company shall at all times maintain provisions in its By-laws and/or Certificate of Incorporation indemnifying all directors against liability and absolving all directors from liability to the Company and its stockholders to the maximum extent permitted under the laws of the State of Delaware. (b) The By-laws of the Company shall always contain provisions consistent with the provisions of this Section 7.17 except to the extent this Section 7.17 deals with the possible observer. 7.18. Certain Subsidiaries. Except for wholly owned subsidiaries of the Company., the Company will not create any entity that would be a Subsidiary (as defined in Section 9.9) without the prior written consent of the Purchasers. Notwithstanding the foregoing, the Company may acquire any interest in any business from any person, firm or entity (whether by a purchase of assets, purchase of stock, merger or otherwise) using cash or stock without the prior written consent of the Purchasers. 7.19. Listing. The Company will take all action necessary promptly to file an Application for Listing of Additional Shares with Nasdaq National Market and/or take any other necessary action to enable the Common Stock to trade on a national market. 7.20. Material Changes. The Company will promptly notify the Purchasers of any material adverse change in its business or financial condition. 7.21. Adjustment to Per Share Price. If, commencing on the date that is six months from the Closing Date and ending on the date that is one year from the Closing Date, the Company issues shares of Common Stock, or securities convertible into or exercisable for shares of Common Stock, at a 15 price per share less than the Per Share Price, then the Company shall simultaneously issue to the Purchasers for no additional consideration, a number of shares of Common Stock sufficient to reduce the Per Share Price then in effect to equal the "Adjusted Price" (as defined below). For purposes of this section 7.21(b), the term Adjusted Price (which shall not be greater than the Per Share Price then in effect) shall equal a fraction, the numerator of which shall equal (1) the sum of (A) the number of shares of Common Stock outstanding on the record date of such issuance or sale multiplied by the Per Share Price then in effect plus (B) the Total Consideration (as defined below), and the denominator of which shall be the number of shares of Common Stock outstanding on the record date of such issuance or sale plus the maximum number of additional shares of Common Stock issued, sold or issuable upon exercise or conversion of such securities. "Total Consideration" shall mean the total amount, if any, received or receivable by the Company in consideration of the issuance or sale of such securities plus the total consideration, if any, payable to the Company upon exercise thereof. The provisions of this section 7.21(b) shall not apply (i) to issuances of securities in any corporate partnering arrangements (including mergers) consummated by the Company, (ii) to the exercise or conversion of options, warrants or other convertible securities outstanding as of the Closing Date, or (iii) to issuances which, in the aggregate, yield gross proceeds to the Company of less than $250,000. 7.22. Right of First Refusal. In the event that, within the 12 month period following the Closing Date, the Company intends to conduct a private placement of its securities through a placement agent, broker-dealer or finder, pursuant to which it will pay such agent a commission, then the Company shall (a) notify Paramount Capital, Inc. ("Paramount") of such intent in writing detailing the terms of such proposed offering and (b) grant Paramount the right of first refusal to act as placement agent for the Company in such private placement. Paramount shall notify the Company within 15 days of its intent. In the event that Paramount declines to act as placement agent for the Company on the terms proposed to Paramount in the notice and the Company subsequently offers to a third-party the opportunity to act as placement agent on terms more favorable than those offered to Paramount, then the Company must first offer such opportunity to Paramount on such more favorable terms. 8. Registration of Common Stock. 8.1. Registration. (i) Not later than 30 days after the Closing Date, the Company will file with the SEC a shelf registration statement (the "Shelf Registration Statement") with respect to the resale of the Common Shares beneficially owned by Purchasers following the Closing (the "Registrable Securities"). The Company will use its best efforts to effect the registrations, qualifications or compliances (including, without limitation, the execution of any required undertaking to file post-effective amendments, appropriate qualifications under applicable blue sky or other state securities laws and appropriate compliance with applicable securities laws, requirements or regulations) as may be reasonably requested and as would permit or facilitate that sale and distribution of all Registrable Securities until the distribution thereof is complete; provided that the Company shall not be obligated to maintain the effectiveness of the Shelf Registration Statement (and any related qualifications and compliance) following such time as the Company shall deliver an opinion of counsel reasonably satisfactory to the holders of Registrable Securities (the "Holders') and in form and substance satisfactory to each Holder 16 that (i) such Holders may sell in a single transaction all Registrable Securities then held or issuable to such Holder on a registered securities exchange or Nasdaq market under an applicable exemption from the registration requirements of the Securities Act and all other applicable securities laws and (ii) all transfer restrictions and restrictive legends with respect to such Registrable Securities will be removed upon the consummation of such sale. 8.2. Registration Procedures. In connection with the registration of any Registrable Securities under the Securities Act as provided in this Section 8, the Company will use its best efforts, as expeditiously as possible to: (a) Prepare and file with the SEC the Shelf Registration Statement with respect to such Registrable Securities and use its best efforts to cause such Shelf Registration Statement to become effective as expeditiously as possible; (b) Prepare and file with the SEC such amendments and supplements to such Shelf Registration Statement and the prospectus used in connection therewith as may be necessary to keep such Shelf Registration Statement effective until the disposition of all securities in accordance with the intended methods of disposition by the seller or sellers thereof set forth in such Shelf Registration Statement shall be completed, and to comply with the provisions of the Securities Act (to the extent applicable to the Company) with respect to such dispositions; (c) Furnish to each seller of such Registrable Securities such number of copies of such Shelf Registration Statement and of each such amendment and supplement thereto (in each case including all exhibits), such number of copies of the prospectus included in such Shelf Registration Statement (including each preliminary prospectus), in conformity with the requirements of the Securities Act, and such other documents, as such seller may reasonably request, in order to facilitate the disposition of the Registrable Securities owned by such seller; (d) Use its best efforts to register or qualify such Registrable Securities covered by such Shelf Registration Statement under such other securities or blue sky laws of such jurisdictions as any seller reasonably requests, and do any and all other acts and things which may be reasonably necessary or advisable to enable such seller to consummate the disposition in such jurisdictions of the Registrable Securities owned by such seller, except that the Company will not for any such purpose be required to qualify generally to do business as a foreign corporation in any jurisdiction wherein it would not, but for the requirements of this Section 8.2(d) be obligated to be qualified, to subject itself to taxation in any such jurisdiction, or to consent to general service of process in any such jurisdiction; (e) Provide a transfer agent and registrar for all such Registrable Securities covered by such Shelf Registration Statement not later than the effective date of such Shelf Registration Statement; (f) Notify each seller of such Registrable Securities at any time when a prospectus relating thereto is required to be delivered under the Securities Act, of the happening of any event as a result of which the prospectus included in such Shelf Registration Statement contains an untrue 17 statement of a material fact or omits any fact necessary to make the statements therein not misleading, and, at the request of any such seller, the Company will prepare a supplement or amendment to such prospectus so that, as thereafter delivered to the purchasers of such Registrable Securities, such prospectus will not contain an untrue statement of a material fact or omit to state any fact necessary to make the statements therein not misleading. The Purchasers agree to suspend, upon request of the Company, any disposition of Registrable Securities pursuant to the Registration Statement contemplated hereby during any period, not to exceed one 30-day period per circumstance or development. (g) Cause all such Registrable Securities to be listed on each securities exchange or automated over-the-counter trading system on which similar securities issued by the Company are then listed; (h) Enter into such customary agreements (including, in the event Purchasers elect to engage an underwriter in connection with the Shelf Registration Statement, an underwriting agreement containing customary terms and conditions) and take all such other actions as reasonably required in order to expedite or facilitate the disposition of such Registrable Securities; and (i) Make available for inspection by any seller of Registrable Securities, all financial and other records, pertinent corporation documents and properties of the Company, and cause the Company's officers, directors and employees to supply all information reasonably requested by any such seller in connection with the Shelf Registration Statement pursuant to Section 8.1. 8.3 Registration and Selling Expenses. (a) All expenses incurred by the Company in connection with the Company's performance of or compliance with this

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