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i'm cherie boscher at the annual meeting of the pacific dermatologic association dr vera price is an expert on hair thinning in women she thinks of it as three distinct stages that are age related but not necessarily androgen related well hair thinning occurs at three different stages and we divide the stages based on the age of onset of the thinning so typically uh if thinning starts somewhere in the teens 20s 30s up to the age of 40 approximately we call it androgenetic alopecia this is the typical male and female pattern thinning that we're all familiar with and if thinning starts in the late decades 60s 70s 80s and older we were calling that senescent thinning or age-related thinning and we now know that in women there's an in-between group where the thinning seems to start for the first time somewhere between 45 and 55 and this is a less well-defined group which is now being called female pattern hair loss where the role of androgens isn't as clear-cut as it is in the early onset group the tendency has been to think of thinning if you know you have uh androgenetic alopecia in your early years and you continue to thin in your late years there's been the thinking that that's just a continuum that it's part of the same process and we now know that hormonally the enzymes responsible for androgenetic alopecia namely 5-alpha reductase type 1 and type 2 their levels are way down in the later decades and we also know that if we do gene array studies they look entirely different if we take a group of men and look at these patterns and then the early onset group and the age-related late onset group and we also know what i like to use as my most compelling bit of evidence that it's not just a continuum uh it's not and it's not a dihydrotestosterone mediated event as androgenetic alopecia is in both men and women it's it if we look at the men who have been using five milligrams of which is known as for their enlarged prostates benign prostatic hypertrophy if the age-related thinning was due to a dht mediated phenomenon those men should be regrowing their hair and they are not regrowing their hair so i think that's a very compelling argument that senescent thinning that occurs in our late decades which i like to call age-related or wisdom-related thinning that is not a dihydrotestosterone-mediated event and in our later decades the will not be particularly effective in that later group some treatments work for all three stages and some don't the nice thing is that minoxidil will work in all three groups so if you use it properly it should be effective in all the groups and the thing about minoxidil is it works slowly and it takes time to see the effect but if you have a follicle that's not fully expressing its full...
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