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Populate signatory age

[MUSIC] What I'm going to tell you about today is really as we take a closer look at aging, we'll start by talking about what is aging. What are the challenges that aging poses to individuals and to society at large? We're going to talk about the key solution to those challenges. To do that, we're going to talk about what causes aging at both the cellular and molecular level. Really, the solution to this is going to require a fundamental change to our approach to research. That is really going to be required to have the maximum impact on human health. Lastly, I'll tell you about some of the important breakthroughs that we're making in my laboratory to really make that fountain of youth or reality. Let's start by talking about what aging actually is. If you look up aging in the dictionary, you get the simple definition of it's the process of getting older. It's time passes and unfortunately, I can't tell you how we can prevent time to pass. You might have to attend a lecture in the physics department or something like that to get the answer but we really want to talk about what biological aging is. The World Health Organization defines biological aging as something that results from the impact of the accumulation of a wide variety of molecular and cellular damage over time. This leads to a gradual decrease in physical and mental capacity and a growing risk of disease and ultimately death. Doesn't sound great, does it? This is really the crux of this major health problem, is that by the time we turn 28 years old, aging becomes the leading risk factor for disease and death. This is all kinds of diseases. Cardiovascular disease, dementia, cancer, outcomes from COVID-19, and the list goes on and on. Hearing loss, cataracts, back and neck pain, arthritis, osteoporosis, pulmonary disease, diabetes, depression. The incidence of all of these diseases increases exponentially with aging. Aging is a critical risk factor for our health. But this isn't only true for us as individuals, but really also true for us as a society. Aging is really a public health issue as well. That's because we're in the midst of a massive change in how our population is aging. We're right smack in the middle of a century of change where the population in the United States is changing from an age distribution that's shaped like a pyramid to one that's shaped like a pillar where you have equal distribution across all of these different age groups. Within a few years, for the first time in our history, we will have more people over the age of 65 than we do children under the age of 18. For a long time. Aging has been thought to be this challenge in the developing world. But that's not even true anymore. In fact, the growth of the aging population is increasing even faster in developing countries. By 2030, one in...